Peptide

Norine ID: NOR00616
DOI: 10.26097/nor00616
Family: geodiamolide
Synonym(s): geodiamolide TA;
Activity: antitumor, toxin
Category: peptide
Formula: C30H44ClN3O6
Monoisotopic mass: 577.291863865 g/mol
Comment: Geodiamolides are putative NRPS products (no synthetase genes identified)
Source: norine
Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
Entry information:
- status: putative - change status to non-NRP (Norine validators only)

Type: cyclic
Number of monomers: 4
Smiles: C[C@@H]\1C[C@@H](OC(=O)[C@@H](NC(=O)[C@H](N(C(=O)[C@@H](NC(=O)[C@H](C/C(=C1)/C)C)C)C)CC2=CC(=C(C=C2)O)Cl)C(C)C)C
Graph inference:

Monomeric composition :

C9:1(4)-Me(2.4.6)-OH(8)

Ala

D-Cl-NMe-Tyr

Val

Graph representation: C9:1(4)-Me(2.4.6)-OH(8),Ala,D-Cl-NMe-Tyr,Val @1,3 @0,2 @1,3 @0,2
Atomic structure:

vizualisation:

Links between organisms producing the geodiamolide TA: hemiasterella minor

Hemiasterlin and geodiamolide TA: two new cytotoxic peptides from the marine sponge hemiasterella minor
Pannell LK, Benayahu Y, Kashman Y, Schleyer M, Talpir R, Tetrahedron letters , 1994, 35 (25), pp. 4453-4456

Norine