geodiamolide H
- Norine ID: NOR00601
- DOI: 10.26097/nor00601
- Family: geodiamolide
- Synonym(s): geodiamolide H;
- Activity: toxin
- Category: peptide
- Formula: C34H44IN3O7
- Monoisotopic mass: 733.222393777 g/mol
- Comment: Geodiamolides are putative NRPS products (no synthetase genes identified)
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: putative - change status to non-NRP (Norine validators only)
- last modification date: 2019-04-04 by Maude Pupin [Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
- view all entry history
- Type: cyclic
- Number of monomers: 4
- Smiles: CC2C=C(C)CC(C)C(=O)NC(C)C(=O)N(C)C(Cc1ccc(O)c(c1)I)C(=O)NC(CC(=O)OC(C)C2)c3ccc(O)cc3
- Graph inference:
- Monomeric composition :
1 C9:1(4)-Me(2.4.6)-OH(8) -Me(2.4.6)-OH(8).png "C9:1(4)-Me(2.4.6)-OH(8) chemical structure")
2 Ala 
3 D-I-NMe-Tyr 
4 bTyr 
- Graph representation: C9:1(4)-Me(2.4.6)-OH(8),Ala,D-I-NMe-Tyr,bTyr @1,3 @0,2 @1,3 @0,2
- Atomic structure:
vizualisation:
- Geodia
- taxid: 6046 (view NCBI taxonomy browser)
- Links between organisms producing the geodiamolide H: Geodia
- Geodiamolides H and I, further cyclodepsipeptides from the marine sponge Geodia sp.
Tinto WF, Lough AJ, McLean S, Reynolds WF, Yu M, Chan WR, Tetrahedron , 1998, 54 (18), pp. 4451-4458
- The geodiamolide H, derived from brazilian sponge Geodia corticostylifera, regulates actin cytoskeleton, migration and invasion of breast cancer cells cultured in three-dimensional environment
Freitas VM, Rangel M, Bisson LF, Jaeger RG, Machado-Santelli GM, Journal of cellular physiology , 2008, Sep,216(3):583-94.
DOI: 10.1002/jcp.21432
pubMed: 18330887
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