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aciculitin A


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  • Norine ID: NOR00600
  • DOI: 10.26097/nor00600
  • Family: aciculitin
  • Synonym(s): aciculitin A;
  • Activity: antimicrobial, toxin
  • Category: glycopeptide
  • Formula: C61H86N14O21
  • Monoisotopic mass: 1350.609195884 g/mol
  • Comment: Aciculitins are putative NRPS products (no synthetase genes identified).
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: putative - change status to non-NRP (Norine validators only)
    • last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
    • view all entry history
  • Type: double cyclic
  • Number of monomers: 11
  • Smiles: CCCCCCC=CC=CC(OC1OCC(O)C(O)C1(O))C(O)C(=O)NC(=CC)C(=O)NC4C(C)NC(=O)C5Cc2[nH]cnc2c3cc(ccc3(O))CC(NC(=O)C(NC4(=O))C(C)O)C(=O)NC(=CC)C(=O)NC(C(O)CC(N)=O)C(=O)NCC(=O)NC(CCC(N)=O)C(=O)N5

  • Graph inference:



  • Monomeric composition :
    1
    aThr
    2
    Tyr
    3
    dhAbu
    4
    bOH-Gln
    5
    Gly
    6
    Gln
    7
    His
    8
    Dab
    9
    C13:2(t4.t6)-OH(2.3)
    10
    Lyx
    11
    dhAbu
  • Graph representation: aThr,Tyr,dhAbu,bOH-Gln,Gly,Gln,His,Dab,C13:2(t4.t6)-OH(2.3),Lyx,dhAbu @7,1 @0,2,6 @1,3 @2,4 @3,5 @4,6 @7,5,1 @10,0,6 @9,10 @8 @8,7

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Aciculites orientalis
  • taxid: 1562474 (view NCBI taxonomy browser)

  • Links between organisms producing the aciculitin A: Aciculites orientalis
  • Aciculitins A-C: Cytotoxic and antifungal cyclic peptides from the lithistid sponge Aciculites orientalis
    Williams DH, Faulkner DJ, Bewley CA, He H, Journal of the American Chemical Society , 1996, 118 (18), pp. 4314-4321


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