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microsclerodermin E


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  • Norine ID: NOR00555
  • DOI: 10.26097/nor00555
  • Family: microsclerodermin
  • Synonym(s): microsclerodermin E;
  • Activity: antimicrobial
  • Category: peptide
  • Formula: C45H54N8O14
  • Monoisotopic mass: 930.375948476 g/mol
  • Comment: Microsclerodermins are putative NRPS products (no synthetase genes identified)
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: cyclic
  • Number of monomers: 6
  • Smiles: CCOC1=CC=C(C=C1)/C=C/C=C/C[C@@H]([C@H]([C@@H]2[C@@H](C(=O)N[C@@H]\3CC(=O)N/C3=C/C(=O)N(CC(=O)N[C@@H](C(=O)NCC(=O)NC[C@@H](CC(=O)N2)O)CC4=C(NC5=CC=CC=C54)C(=O)O)C)O)O)O

  • Graph inference:



  • Monomeric composition :
    1
    C10:2(7.9)-OH(2.4.5)-NH2(3)-ePh(10)
    2
    dPyr
    3
    NMe-Gly
    4
    D-COOH-Trp
    5
    Gly
    6
    OH-4Abu
  • Graph representation: C10:2(7.9)-OH(2.4.5)-NH2(3)-ePh(10),dPyr,NMe-Gly,D-COOH-Trp,Gly,OH-4Abu @1,5 @0,2 @1,3 @2,4 @3,5 @0,4

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Microscleroderma sp.

  • Links between organisms producing the microsclerodermin E: Microscleroderma sp.
  • Microsclerodermins C - E, antifungal cyclic peptides from the lithistid marine sponges Theonella sp. and Microscleroderma sp
    Faulkner DJ, Schmidt EW, Tetrahedron , 1998, 4 (13), pp. 3043-3056


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