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phakellistatin 1


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  • Norine ID: NOR00523
  • DOI: 10.26097/nor00523
  • Family: phakellistatin
  • Synonym(s): phakellistatin 1;
  • Activity: antitumor
  • Category: peptide
  • Formula: C45H61N7O8
  • Monoisotopic mass: 827.4581619630001 g/mol
  • Comment: Phakellistatins are putative NRPS products (no synthetase genes identified)
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: cyclic
  • Number of monomers: 7
  • Smiles: CCC(C)C3NC(=O)C6CCCN6(C(=O)C(NC(=O)C5CCCN5(C(=O)C(Cc1ccc(O)cc1)NC(=O)C4CCCN4(C(=O)C(Cc2ccccc2)NC3(=O))))C(C)CC)

  • Graph inference:



  • Monomeric composition :
    1
    Pro
    2
    Tyr
    3
    Pro
    4
    Ile
    5
    Pro
    6
    Ile
    7
    Phe
  • Graph representation: Pro,Tyr,Pro,Ile,Pro,Ile,Phe @1,6 @0,2 @1,3 @2,4 @3,5 @4,6 @0,5

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Stylotella aurantium

  • Phakellia sp.

  • Links between organisms producing the phakellistatin 1: Stylotella aurantium, Phakellia sp.
  • Isolation and structure of the marine sponge cell growth inhibitory cyclic peptide phakellistatin 1
    Pettit GR, Doubek DL, Tackett LP, Schmidt JM, Cichacz Z, Barkoczy J, Dorsaz AC, Herald DL, Williams MD, Brune DC, Journal of natural products , 1993, Feb,56(2):260-7.
    DOI: 10.1021/np50092a011
    pubMed: 8463798


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