Norine

home > NRP > norine

kapakahine A


Get HTML       

  • Norine ID: NOR00480
  • DOI: 10.26097/nor00480
  • Family: kapakahine
  • Synonym(s): kapakahine A;
  • Activity: toxin
  • Category: peptide
  • Formula: C58H72N10O9
  • Monoisotopic mass: 1052.548373952 g/mol
  • Comment: Kapakahines share a unique structural feature: two tryptophan residues (Trp-1 and -2) are not linked by an amide bond but by a N-C bond from the indole nitrogen of Trp-1 to the indole carbon of Trp-2.Kapakahines C and D differ from A by the addition of the elements of H2O to the indole double bond of Trp-1 together with the formation of a bond between C-4 and N-1.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: putative - change status to non-NRP (Norine validators only)
    • last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
    • view all entry history
  • Type: other
  • Number of monomers: 8
  • Monomeric composition :
    1
    Tyr
    2
    Trp
    3
    Ile
    4
    Pro
    5
    Val
    6
    Pro
    7
    Ile
    8
    Trp
  • Graph representation: Tyr,Trp,Ile,Pro,Val,Pro,Ile,Trp @1,1 @0,0,2,7 @1,3 @2,4 @3,5 @4,6 @5,7 @1,6

  • Atomic structure:

    • Peptide's atomic structure image is not available because smiles is not present.

  • Cribrochalina olemda

  • Links between organisms producing the kapakahine A: Cribrochalina olemda
  • The Kapakahines, Cyclic Peptides from the Marine Sponge Cribrochalina olemda
    Scheuer PJ, Nakao Y, Yoshida WY, Yeung BK, Kinnel RB, Carney JR, Kelly-Borges M, The Journal of organic chemistry , 1996, Oct 4,61(20):7168-7173.
    DOI: 10.1021/jo960725e
    pubMed: 11667621


back Return to annotations search