kapakahine A
- Norine ID: NOR00480
- DOI: 10.26097/nor00480
- Family: kapakahine
- Synonym(s): kapakahine A;
- Activity: toxin
- Category: peptide
- Formula: C58H72N10O9
- Monoisotopic mass: 1052.548373952 g/mol
- Comment: Kapakahines share a unique structural feature: two tryptophan residues (Trp-1 and -2) are not linked by an amide bond but by a N-C bond from the indole nitrogen of Trp-1 to the indole carbon of Trp-2.Kapakahines C and D differ from A by the addition of the elements of H2O to the indole double bond of Trp-1 together with the formation of a bond between C-4 and N-1.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: putative - change status to non-NRP (Norine validators only)
- last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- view all entry history
- Type: other
- Number of monomers: 8
- Monomeric composition :
1 Tyr 2 Trp 3 Ile 4 Pro 5 Val 6 Pro 7 Ile 8 Trp - Graph representation: Tyr,Trp,Ile,Pro,Val,Pro,Ile,Trp @1,1 @0,0,2,7 @1,3 @2,4 @3,5 @4,6 @5,7 @1,6
- Atomic structure:
Peptide's atomic structure image is not available because smiles is not present.
- Cribrochalina olemda
- Links between organisms producing the kapakahine A: Cribrochalina olemda
- The Kapakahines, Cyclic Peptides from the Marine Sponge Cribrochalina olemda
Scheuer PJ, Nakao Y, Yoshida WY, Yeung BK, Kinnel RB, Carney JR, Kelly-Borges M, The Journal of organic chemistry , 1996, Oct 4,61(20):7168-7173.
DOI: 10.1021/jo960725e
pubMed: 11667621
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