Peptide

Norine ID: NOR00455
DOI: 10.26097/nor00455
Family: halipeptin
Synonym(s): halipeptin D;
Activity: antiinflammatory
Category: peptide
Formula: C31H54N4O6S
Monoisotopic mass: 610.37640618 g/mol
Comment: Halipeptin is a putative NRPS product (no synthetase genes identified).
Source: norine
Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
Entry information:
- status: putative - change status to non-NRP (Norine validators only)

Type: cyclic
Number of monomers: 5
Smiles: CCC[C@@H](CC[C@@H](C)[C@H]1C(C(=O)N[C@H](C2=N[C@@](CS2)(C(=O)N([C@H](C(=O)N[C@H](C(=O)O1)C)[C@@H](C)CC)C)C)C)(C)C)OC
Graph inference:

Monomeric composition :

C10:0-Me(2.2.4)-OH(3)-OMe(7)

Ala

aMe-Cys

NMe-Ile

Ala

Graph representation: C10:0-Me(2.2.4)-OH(3)-OMe(7),Ala,aMe-Cys,NMe-Ile,Ala @1,4 @0,2 @1,3 @2,4 @0,3
Atomic structure:

vizualisation:

Links between organisms producing the halipeptin D: Leiosella cf. arenifibrosa

Total synthesis of halipeptins: isolation of halipeptin D and synthesis of oxazoline halipeptin analogues
Nicolaou KC, Schlawe D, Kim DW, Longbottom DA, de Noronha RG, Lizos DE, Manam RR, Faulkner DJ, Chemistry , 2005, Oct 21,11(21):6197-211.
DOI: 10.1002/chem.200500624
pubMed: 16075448

Norine