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polydiscamide A


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  • Norine ID: NOR00446
  • DOI: 10.26097/nor00446
  • Family: polydiscamide
  • Synonym(s): polydiscamide A;
  • Activity: antimicrobial, antitumor
  • Category: peptide
  • Formula: C75H109BrN19O20S
  • Monoisotopic mass: 1706.700035723 g/mol
  • Comment: Polydiscamides are putative NRPS products (no synthetase genes identified).
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: putative - change status to non-NRP (Norine validators only)
    • last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
    • view all entry history
  • Type: partial cyclic
  • Number of monomers: 13
  • Monomeric composition :
    1
    D-NFo-Ala
    2
    Br-Phe
    3
    Pro
    4
    D-t-Leu
    5
    bMe-Ile
    6
    D-Trp
    7
    Arg
    8
    D-CysA
    9
    Thr
    10
    NMe-Gln
    11
    D-Val
    12
    Pro
    13
    D-Asn
  • Graph representation: D-NFo-Ala,Br-Phe,Pro,D-t-Leu,bMe-Ile,D-Trp,Arg,D-CysA,Thr,NMe-Gln,D-Val,Pro,D-Asn @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9,12 @8,10 @9,11 @10,12 @8,11

  • Atomic structure:

    • Peptide's atomic structure image is not available because smiles is not present.

  • Discodermia sp.
  • taxid: 73796 (view NCBI taxonomy browser)

  • Links between organisms producing the polydiscamide A: Discodermia sp.
  • Polydiscamide A: A new bioactive depsipeptide from the marine sponge discodermia sp.
    Gulavita NK, Gunasekera SP, Pomponi SA, Robinson EV, Journal of Organic Chemistry , 1992, 57 (6), pp. 1767-1772


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