Norine

• Norine ID: NOR00372
• DOI: 10.26097/nor00372
• Family: dolastatin
• Synonym(s): dolastatin 12;
• Activity: antitumor
• Category: peptide
• Formula: C50H80N8O11
• Monoisotopic mass: 968.594655442 g/mol
• Comment: Dolastatin 11 and dolastatin 12 inhibit growth of the murine P388 lymphocytic leukemia.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • view all entry history

• Type: cyclic
• Number of monomers: 9
• Smiles: CCC(C)C2OC(=O)C(C)C(CC)NC(=O)C(C)N(C)C(=O)C(C)(C)C(=O)C(C)NC(=O)C(Cc1ccccc1)N(C)C(=O)C(C(C)C)N(C)C(=O)CNC(=O)C(CC(C)C)N(C)C(=O)CNC2(=O)
  
  
• Graph inference:


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• Monomeric composition :

  1 Gly

  2 NMe-Val

  3 NMe-Tyr

  4 Ibu

  5 NMe-Ala

  6 Map

  7 Hmp

  8 Gly

  9 NMe-Leu

• Graph representation: Gly,NMe-Val,NMe-Tyr,Ibu,NMe-Ala,Map,Hmp,Gly,NMe-Leu @1,8 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @0,7
  
  
• Atomic structure:

vizualisation:

• Dolabella auricularia
• taxid: 6511 (view NCBI taxonomy browser)

• Links between organisms producing the dolastatin 12: Dolabella auricularia

• Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11
  Bates RB, Brusoe KG, Burns JJ, Caldera S, Cui W, Gangwar S, Gramme MR, Bontems R, Journal of the American Chemical Society , 1997, 119 (9), pp. 2111-2113
  

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