dolastatin 11
- Norine ID: NOR00371
- DOI: 10.26097/nor00371
- Family: dolastatin
- Synonym(s): dolastatin 11;
- Activity: antitumor
- Category: peptide
- Formula: C50H80N8O12
- Monoisotopic mass: 984.589570064 g/mol
- Comment: Dolastatin 11 and dolastatin 12 inhibit growth of the murine P388 lymphocytic leukemia.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: cyclic
- Number of monomers: 9
- Smiles: CCC(C)C2OC(=O)C(C)C(CC)NC(=O)C(C)NC(=O)C(C)(C)C(=O)C(C)NC(=O)C(Cc1ccc(cc1)OC)N(C)C(=O)C(C(C)C)N(C)C(=O)CNC(=O)C(CC(C)C)N(C)C(=O)CNC2(=O)
- Graph inference:
- Monomeric composition :
1 Gly 2 NMe-Val 3 NMe-OMe-Tyr 4 Ibu 5 Ala 6 Map 7 Hmp 8 Gly 9 NMe-Leu - Graph representation: Gly,NMe-Val,NMe-OMe-Tyr,Ibu,Ala,Map,Hmp,Gly,NMe-Leu @1,8 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @0,7
- Atomic structure:
- Dolabella auricularia
- taxid: 6511 (view NCBI taxonomy browser)
- Links between organisms producing the dolastatin 11: Dolabella auricularia
- Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11
Bates RB, Brusoe KG, Burns JJ, Caldera S, Cui W, Gangwar S, Gramme MR, Bontems R, Journal of the American Chemical Society , 1997, 119 (9), pp. 2111-2113
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