Norine

• Norine ID: NOR00343
• DOI: 10.26097/nor00343
• Family: amphisin
• Synonym(s): arthrofactin;
• Activity: surfactant, antimicrobial
• Category: lipopeptide
• Formula: C64H111N11O20
• Monoisotopic mass: 1353.8006850470001 g/mol
• Comment: Arthrofactin was found to be five to seven times more effective than surfactin.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 12
• Smiles: CCCCCCCC1CC(=O)NC(CC(C)C)C(=O)NC(CC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(C(C)CC)C(=O)NC(CC(=O)O)C(=O)O1
  
  
• Graph inference:


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• Monomeric composition :

  1 C10:0-OH(3)	2 D-Leu	3 D-Asp	4 D-Thr	5 D-Leu	6 D-Leu	7 D-Ser	8 Leu	9 D-Ser	10 Ile	11 Ile	12 Asp

• Graph representation: C10:0-OH(3),D-Leu,D-Asp,D-Thr,D-Leu,D-Leu,D-Ser,Leu,D-Ser,Ile,Ile,Asp @1 @0,2 @1,3 @2,4,11 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @3,10
  
  
• Atomic structure:

vizualisation:

• Pseudomonas sp. MIS38
• gram: negative
• taxid: 91465 (view NCBI taxonomy browser)

• Arthrobacter sp.
• gram: positive
• taxid: 1667 (view NCBI taxonomy browser)

• Links between organisms producing the arthrofactin: Pseudomonas sp. MIS38, Arthrobacter sp.

• Cloning and characterization of the gene cluster encoding arthrofactin synthetase from Pseudomonas sp. MIS38
  Roongsawang N, Hase K, Haruki M, Imanaka T, Morikawa M, Kanaya S, Chemistry and biology , 2003, Sep,10(9):869-80.
  pubMed: 14522057

• A new lipopeptide biosurfactant produced by Arthrobacter sp. strain MIS38
  Imanaka T, Morikawa M, Daido H, Takao T, Murata S, Shimonishi Y, Journal of bacteriology , 1993, Oct,175(20):6459-66.
  DOI: 10.1128/jb.175.20.6459-6466.1993
  pubMed: 8407822

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