tyrocidine D
- Norine ID: NOR00301
- DOI: 10.26097/nor00301
- Family: tyrocidine
- Synonym(s): tyrocidine D;
- Activity: antimicrobial
- Category: peptide
- Formula: C72H90N16O12
- Monoisotopic mass: 1370.692412424 g/mol
- Comment: Tyrocidine kills bacteria by interacting with their cytoplasmic membrane and causing leakage of their intracellular content. It also affects intracellular membranes such as those of mitochondria.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: cyclic
- Number of monomers: 10
- Smiles: CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN)C(C)C)CC3=CNC4=CC=CC=C43)CCC(=O)N)CC(=O)N)CC5=CNC6=CC=CC=C65)CC7=CNC8=CC=CC=C87)CC9=CC=CC=C9
- Graph inference:
- Monomeric composition :
1 D-Phe 2 Pro 3 Trp 4 D-Trp 5 Asn 6 Gln 7 Trp 8 Val 9 Orn 10 Leu - Graph representation: D-Phe,Pro,Trp,D-Trp,Asn,Gln,Trp,Val,Orn,Leu @1,9 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @0,8
- Atomic structure:
- Bacillus brevis
- gram: positive
- synonyms: Brevibacillus brevis
- taxid: 1393 (view NCBI taxonomy browser)
- Links between organisms producing the tyrocidine D: Bacillus brevis
- The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
Mootz HD, Marahiel MA, Journal of bacteriology , 1997, Nov,179(21):6843-50.
DOI: 10.1128/jb.179.21.6843-6850.1997
pubMed: 9352938
Return to annotations search