Norine

• Norine ID: NOR00298
• DOI: 10.26097/nor00298
• Family: tyrocidine
• Synonym(s): tyrocidine A;
• Activity: antimicrobial
• Category: peptide
• Formula: C66H87N13O13
• Monoisotopic mass: 1269.654629935 g/mol
• Comment: Tyrocidine kills bacteria by interacting with their cytoplasmic membrane and causing leakage of their intracellular content. It also affects intracellular membranes such as those of mitochondria.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 10
• Smiles: CC(C)CC5NC(=O)C(CCCN)NC(=O)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccccc3)NC(=O)C6CCCN6(C(=O)C(Cc4ccccc4)NC5(=O)))C(C)C
  
  
• Graph inference:


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• Monomeric composition :

  1 D-Phe

  2 Pro

  3 Phe

  4 D-Phe

  5 Asn

  6 Gln

  7 Tyr

  8 Val

  9 Orn

  10 Leu

• Graph representation: D-Phe,Pro,Phe,D-Phe,Asn,Gln,Tyr,Val,Orn,Leu @1,9 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @0,8
  
  
• Atomic structure:

vizualisation:

• Bacillus brevis
• gram: positive
• synonyms: Brevibacillus brevis
• taxid: 1393 (view NCBI taxonomy browser)

• Links between organisms producing the tyrocidine A: Bacillus brevis

• The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
  Mootz HD, Marahiel MA, Journal of bacteriology , 1997, Nov,179(21):6843-50.
  DOI: 10.1128/jb.179.21.6843-6850.1997
  pubMed: 9352938

  P09095 O30408 O30409

  16129635

  CHEMBL408504