PF1022A
- Norine ID: NOR00289
- DOI: 10.26097/nor00289
- Family: PF1022
- Synonym(s): PF1022A;
- Activity: antimicrobial
- Category: peptide
- Formula: C52H76N4O12
- Monoisotopic mass: 948.545973916 g/mol
- Comment: It possesses strong anthelmintic properties.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: cyclic
- Number of monomers: 8
- Smiles: CC(C)CC3C(=O)OC(Cc1ccccc1)C(=O)N(C)C(CC(C)C)C(=O)OC(C)C(=O)N(C)C(CC(C)C)C(=O)OC(Cc2ccccc2)C(=O)N(C)C(CC(C)C)C(=O)OC(C)C(=O)N3(C)
- Graph inference:
- Monomeric composition :
1 D-Ph-Lac 2 NMe-Leu 3 D-Lac 4 NMe-Leu 5 D-Ph-Lac 6 NMe-Leu 7 D-Lac 8 NMe-Leu - Graph representation: D-Ph-Lac,NMe-Leu,D-Lac,NMe-Leu,D-Ph-Lac,NMe-Leu,D-Lac,NMe-Leu @1,7 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @0,6
- Atomic structure:
- Rosellinia sp. PF1022
- taxid: 241238 (view NCBI taxonomy browser)
- Links between organisms producing the PF1022A: Rosellinia sp. PF1022
- PF1022A and related cyclodepsipeptides: a novel class of anthelmintics
Scherkenbeck J, Jeschke P, Harder A, Current topics in medicinal chemistry , 2002, Jul,2(7):759-77.
DOI: 10.2174/1568026023393624
pubMed: 12052189
- Biosynthesis of PF1022A and related cyclooctadepsipeptides
Zocher R, Weckwerth W, Miyamoto K, Iinuma K, Krause M, Glinski M, Storm T, Bonse G, Kleinkauf H, The Journal of biological chemistry , 2000, Jun 9,275(23):17909-15.
DOI: 10.1074/jbc.M001084200
pubMed: 10751395
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