Norine

• Norine ID: NOR00289
• DOI: 10.26097/nor00289
• Family: PF1022
• Synonym(s): PF1022A;
• Activity: antimicrobial
• Category: peptide
• Formula: C52H76N4O12
• Monoisotopic mass: 948.545973916 g/mol
• Comment: It possesses strong anthelmintic properties.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 8
• Smiles: CC(C)CC3C(=O)OC(Cc1ccccc1)C(=O)N(C)C(CC(C)C)C(=O)OC(C)C(=O)N(C)C(CC(C)C)C(=O)OC(Cc2ccccc2)C(=O)N(C)C(CC(C)C)C(=O)OC(C)C(=O)N3(C)
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 D-Ph-Lac

  2 NMe-Leu

  3 D-Lac

  4 NMe-Leu

  5 D-Ph-Lac

  6 NMe-Leu

  7 D-Lac

  8 NMe-Leu

• Graph representation: D-Ph-Lac,NMe-Leu,D-Lac,NMe-Leu,D-Ph-Lac,NMe-Leu,D-Lac,NMe-Leu @1,7 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @0,6
  
  
• Atomic structure:

vizualisation:

• Rosellinia sp. PF1022
• taxid: 241238 (view NCBI taxonomy browser)

• Links between organisms producing the PF1022A: Rosellinia sp. PF1022

• PF1022A and related cyclodepsipeptides: a novel class of anthelmintics
  Scherkenbeck J, Jeschke P, Harder A, Current topics in medicinal chemistry , 2002, Jul,2(7):759-77.
  DOI: 10.2174/1568026023393624
  pubMed: 12052189

• Biosynthesis of PF1022A and related cyclooctadepsipeptides
  Zocher R, Weckwerth W, Miyamoto K, Iinuma K, Krause M, Glinski M, Storm T, Bonse G, Kleinkauf H, The Journal of biological chemistry , 2000, Jun 9,275(23):17909-15.
  DOI: 10.1074/jbc.M001084200
  pubMed: 10751395

  159590

  CHEMBL186158