Norine

• Norine ID: NOR00281
• DOI: 10.26097/nor00281
• Family: aureobasidin
• Synonym(s): aureobasidin A;
• Activity: antimicrobial
• Category: peptide
• Formula: C60H92N8O11
• Monoisotopic mass: 1100.688555826 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 9
• Smiles: CCC(C)C3NC(=O)C4CCCN4(C(=O)C(Cc1ccccc1)N(C)C(=O)C(Cc2ccccc2)NC(=O)C(C(C)C)N(C)C(=O)C(OC(=O)C(N(C)C(=O)C(CC(C)C)NC(=O)C(C(C)C)N(C)C3(=O))C(C)(C)O)C(C)CC)
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 D-Hmp

  2 NMe-Val

  3 Phe

  4 NMe-Phe

  5 Pro

  6 aIle

  7 NMe-Val

  8 Leu

  9 bOH-NMe-Val

• Graph representation: D-Hmp,NMe-Val,Phe,NMe-Phe,Pro,aIle,NMe-Val,Leu,bOH-NMe-Val @1,8 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @0,7
  
  
• Atomic structure:

vizualisation:

• Aureobasidium pullulans
• gram:
• synonyms:
• taxid: 5580 (view NCBI taxonomy browser)

• Links between organisms producing the aureobasidin A: Aureobasidium pullulans

• Aureobasidins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC-transporter
  Tiberghien F, Kurome T, Takesako K, Didier A, Wenandy T, Loor F, Journal of medicinal chemistry , 2000, Jun 29,43(13):2547-56.
  DOI: 10.1021/jm990955w
  pubMed: 10891114

  72050