Norine

• Norine ID: NOR00125
• DOI: 10.26097/nor00125
• Family: microcystin
• Synonym(s): microcystin LY;
• Activity: toxin
• Category: PK-NRP
• Formula: C52H71N7O13
• Monoisotopic mass: 1001.510985393 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 7
• Smiles: COC(Cc1ccccc1)C(C)C=C(C)C=CC3NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(C)C(NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(=C)N(C)C(=O)CCC(NC(=O)C3(C))C(=O)O)C(=O)O
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 D-Ala

  2 Leu

  3 D-bMe-Asp

  4 Tyr

  5 Adda

  6 D-Glu

  7 NMe-Dha

• Graph representation: D-Ala,Leu,D-bMe-Asp,Tyr,Adda,D-Glu,NMe-Dha @1,6 @0,2 @1,3 @2,4 @3,5 @4,6 @0,5
  
  
• Atomic structure:

vizualisation:

• Microcystis aeruginosa
• taxid: 1126 (view NCBI taxonomy browser)

• Links between organisms producing the microcystin LY: Microcystis aeruginosa

• The effects of single L-amino acid substitutions on the lethal potencies of the microcystins
  Stoner RD, Adams WH, Slatkin DN, Siegelman HW, Toxicon , 1989, 27(7):825-8.
  DOI: 10.1016/0041-0101(89)90051-2
  pubMed: 2506678

  Q9RNB1 Q9RNB0 Q9RNA9 Q9RNB3 Q9RNB5

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