Norine

• Norine ID: NOR00110
• DOI: 10.26097/nor00110
• Family: microcystin
• Synonym(s): microcystin LW;
• Activity: toxin
• Category: PK-NRP
• Formula: C54H72N8O12
• Monoisotopic mass: 1024.526969808 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 7
• Smiles: COC(Cc1ccccc1)C(C)C=C(C)C=CC4NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(C)C(NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(=C)N(C)C(=O)CCC(NC(=O)C4(C))C(=O)O)C(=O)O
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 D-Ala

  2 Leu

  3 D-bMe-Asp

  4 Trp

  5 Adda

  6 D-Glu

  7 NMe-Dha

• Graph representation: D-Ala,Leu,D-bMe-Asp,Trp,Adda,D-Glu,NMe-Dha @1,6 @0,2 @1,3 @2,4 @3,5 @4,6 @0,5
  
  
• Atomic structure:

vizualisation:

• Microcystis viridis
• gram: negative
• taxid: 44822 (view NCBI taxonomy browser)

• Microcystis aeruginosa
• taxid: 1126 (view NCBI taxonomy browser)

• Links between organisms producing the microcystin LW: Microcystis viridis, Microcystis aeruginosa

• Simple assay for analyzing five microcystins and nodularin in fish muscle tissue: hot water extraction followed by liquid chromatography-tandem mass spectrometry
  Bogialli S, Bruno M, Curini R, Di Corcia A, Lagana A, Mari B, Journal of agricultural and food chemistry , 2005, Aug 24,53(17):6586-92.
  DOI: 10.1021/jf050257m
  pubMed: 16104770

  Q9RNB1 Q9RNB0 Q9RNA9 Q9RNB3 Q9RNB5

  16760564