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cyclosporin A


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  • Norine ID: NOR00033
  • DOI: 10.26097/nor00033
  • Family: cyclosporin
  • Synonym(s): cyclosporin A;
  • Activity: immunomodulating, antimicrobial
  • Category: peptide
  • Formula: C62H111N11O12
  • Monoisotopic mass: 1201.841368071 g/mol
  • Comment: Cyclosporin is the primary tool used to prevent rejection following solid organ and bone marrow transplantation. It was first isolated as anti-fungal compound.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: cyclic
  • Number of monomers: 11
  • Smiles: CC=CCC(C)C(O)C1C(=O)NC(CC)C(=O)N(C)CC(=O)N(C)C(CC(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(C(C)C)C(=O)N1(C)

  • Graph inference:



  • Monomeric composition :
    1
    D-Ala
    2
    NMe-Leu
    3
    NMe-Leu
    4
    NMe-Val
    5
    NMe-Bmt
    6
    Abu
    7
    NMe-Gly
    8
    NMe-Leu
    9
    Val
    10
    NMe-Leu
    11
    Ala
  • Graph representation: D-Ala,NMe-Leu,NMe-Leu,NMe-Val,NMe-Bmt,Abu,NMe-Gly,NMe-Leu,Val,NMe-Leu,Ala @1,10 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @0,9

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Tolypocladium inflatum
  • gram:
  • synonyms: Tolypocladium niveum,Beauveria nivea
  • taxid: 29910 (view NCBI taxonomy browser)

  • Links between organisms producing the cyclosporin A: Tolypocladium inflatum
  • Multifunctional Peptide Synthetases
    von Dohren H, Keller U, Vater J, Zocher R, Chemical reviews , 1997, Nov 10,97(7):2675-2706.
    pubMed: 11851477
  • Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described
    Zocher R, Lawen A, The Journal of biological chemistry , 1990, Jul 5,265(19):11355-60.
    pubMed: 2358465


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