cyclosporin A
- Norine ID: NOR00033
- DOI: 10.26097/nor00033
- Family: cyclosporin
- Synonym(s): cyclosporin A;
- Activity: immunomodulating, antimicrobial
- Category: peptide
- Formula: C62H111N11O12
- Monoisotopic mass: 1201.841368071 g/mol
- Comment: Cyclosporin is the primary tool used to prevent rejection following solid organ and bone marrow transplantation. It was first isolated as anti-fungal compound.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: cyclic
- Number of monomers: 11
- Smiles: CC=CCC(C)C(O)C1C(=O)NC(CC)C(=O)N(C)CC(=O)N(C)C(CC(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(C(C)C)C(=O)N1(C)
- Graph inference:
- Monomeric composition :
1 D-Ala 2 NMe-Leu 3 NMe-Leu 4 NMe-Val 5 NMe-Bmt 6 Abu 7 NMe-Gly 8 NMe-Leu 9 Val 10 NMe-Leu 11 Ala - Graph representation: D-Ala,NMe-Leu,NMe-Leu,NMe-Val,NMe-Bmt,Abu,NMe-Gly,NMe-Leu,Val,NMe-Leu,Ala @1,10 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @0,9
- Atomic structure:
- Tolypocladium inflatum
- gram:
- synonyms: Tolypocladium niveum,Beauveria nivea
- taxid: 29910 (view NCBI taxonomy browser)
- Links between organisms producing the cyclosporin A: Tolypocladium inflatum
- Multifunctional Peptide Synthetases
von Dohren H, Keller U, Vater J, Zocher R, Chemical reviews , 1997, Nov 10,97(7):2675-2706.
pubMed: 11851477
- Cyclosporin synthetase. The most complex peptide synthesizing multienzyme polypeptide so far described
Zocher R, Lawen A, The Journal of biological chemistry , 1990, Jul 5,265(19):11355-60.
pubMed: 2358465
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