CDA2fb
- Norine ID: NOR00032
- DOI: 10.26097/nor00032
- Family: Calcium dependent antibiotic
- Synonym(s): CDA2fb;
- Activity: antimicrobial
- Category: lipopeptide
- Formula: C67H81FN14O28P
- Monoisotopic mass: 1579.506637788 g/mol
- Comment: CDA shares a similar structure and possibly a related mode of action to other acidic lipopeptide antibiotics, including daptomycin, friulimicins, and amphomycins.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2019-04-04 by Maude Pupin [Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
- view all entry history
- Type: partial cyclic
- Number of monomers: 12
- Monomeric composition :
1 C6:0-Ep(2) .png "C6:0-Ep(2) chemical structure")
2 Ser 
3 Thr 
4 D-Trp 
5 Asp 
6 Asp
7 D-F-ph-Gly 
8 Asp
9 Gly 
10 D-PO-Asn 
11 3Me-Glu 
12 Trp 
- Graph representation: C6:0-Ep(2),Ser,Thr,D-Trp,Asp,Asp,D-F-ph-Gly,Asp,Gly,D-PO-Asn,3Me-Glu,Trp @1 @0,2 @1,3,11 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @2,10
- Atomic structure:
Peptide's atomic structure image is not available because smiles is not present.
- Streptomyces roseosporus
- gram: positive
- synonyms: Streptomyces filamentosus,Streptomyces venezuelae subsp. roseospori,Streptomyces roseisporus
- taxid: 67294 (view NCBI taxonomy browser)
- Fusarium oxysporum
- taxid: 5507 (view NCBI taxonomy browser)
- Links between organisms producing the CDA2fb: Streptomyces roseosporus, Fusarium oxysporum
- Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor
Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J, Chemistry and biology , 2002, Nov,9(11):1175-87.
pubMed: 12445768
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