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CDA2a


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  • Norine ID: NOR00024
  • DOI: 10.26097/nor00024
  • Family: Calcium dependent antibiotic
  • Synonym(s): CDA2a;
  • Activity: antimicrobial
  • Category: lipopeptide
  • Formula: C67H80N14O29P
  • Monoisotopic mass: 1575.495324168 g/mol
  • Comment: CDA shares a similar structure and possibly a related mode of action to other acidic lipopeptide antibiotics, including daptomycin, friulimicins, and amphomycins.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
    • status: curated - change status to non-NRP (Norine validators only)
    • last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
    • view all entry history
  • Type: partial cyclic
  • Number of monomers: 12
  • Monomeric composition :
    1
    C6:0-Ep(2)
    2
    Ser
    3
    Thr
    4
    D-Trp
    5
    Asp
    6
    Asp
    7
    D-Hpg
    8
    Asp
    9
    Gly
    10
    D-PO-Asn
    11
    3Me-Glu
    12
    dh-Trp
  • Graph representation: C6:0-Ep(2),Ser,Thr,D-Trp,Asp,Asp,D-Hpg,Asp,Gly,D-PO-Asn,3Me-Glu,dh-Trp @1 @0,2 @1,3,11 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @2,10

  • Atomic structure:

    • Peptide's atomic structure image is not available because smiles is not present.

  • Streptomyces roseosporus
  • gram: positive
  • synonyms: Streptomyces filamentosus,Streptomyces venezuelae subsp. roseospori,Streptomyces roseisporus
  • taxid: 67294 (view NCBI taxonomy browser)

  • Tolypocladium inflatum
  • gram:
  • synonyms: Tolypocladium niveum,Beauveria nivea
  • taxid: 29910 (view NCBI taxonomy browser)

  • Links between organisms producing the CDA2a: Streptomyces roseosporus, Tolypocladium inflatum
  • Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor
    Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J, Chemistry and biology , 2002, Nov,9(11):1175-87.
    pubMed: 12445768


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