Norine

• Norine ID: NOR00006
• DOI: 10.26097/nor00006
• Family: ACV
• Synonym(s): ACV;
• Activity: antimicrobial
• Category: peptide
• Formula: C14H25N3O6S
• Monoisotopic mass: 363.146406247 g/mol
• Comment: ACV is the penicillin and cephalosporin precursor.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: linear
• Number of monomers: 3
• Smiles: CC(C)C(NC(=O)C(CS)NC(=O)CCCC(N)C(=O)O)C(=O)O
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Aad

  2 Cys

  3 D-Val

• Graph representation: Aad,Cys,D-Val @1 @0,2 @1
  
  
• Atomic structure:

vizualisation:

• Penicillium chrysogenum
• gram: n/a
• synonyms: Penicillium notatum
• taxid: 5076 (view NCBI taxonomy browser)

• Acremonium chrysogenum
• gram: n/a
• synonyms: Cephalosporium acremonium
• taxid: 5044 (view NCBI taxonomy browser)

• Streptomyces clavuligerus
• gram: positive
• taxid: 1901 (view NCBI taxonomy browser)

• Lysobacter lactamgenus
• gram: positive
• taxid: 39596 (view NCBI taxonomy browser)

• Amycolatopsis lactamdurans
• gram: positive
• synonyms: Nocardia lactamdurans, Streptomyces lactamdurans
• taxid: 1913 (view NCBI taxonomy browser)

• Aspergillus nidulans FGSC A4
• gram: n/a
• synonyms: Emericella nidulans FGSC A4
• taxid: 227321 (view NCBI taxonomy browser)

• Aspergillus oryzae RIB40
• gram: n/a
• taxid: 510516 (view NCBI taxonomy browser)

• Arthroderma benhamiae CBS 112371
• taxid: 663331 (view NCBI taxonomy browser)

• Trichophyton verrucosum HKI 0517
• gram: n/a
• taxid: 663202 (view NCBI taxonomy browser)

• Streptomyces cattleya NRRL 8057 = DSM 46488
• gram: positive
• taxid: 1003195 (view NCBI taxonomy browser)

• Links between organisms producing the ACV: Penicillium chrysogenum, Acremonium chrysogenum, Streptomyces clavuligerus, Lysobacter lactamgenus, Amycolatopsis lactamdurans, Aspergillus nidulans FGSC A4, Aspergillus oryzae RIB40, Arthroderma benhamiae CBS 112371, Trichophyton verrucosum HKI 0517, Streptomyces cattleya NRRL 8057 = DSM 46488

• Molecular Biology of Penicillin and Cephalosporin Biosynthesis
  Queener SW, Antimicrobial agents and chemotherapy , 1990, Jun,34(6):943-8.
  DOI: 10.1128/aac.34.6.943
  pubMed: 2203307

• delta-L-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase: the order of peptide bond formation and timing of the epimerisation reaction
  Shiau CY, Baldwin JE, Byford MF, Sobey WJ, Schofield CJ, FEBS letters , 1995, Jan 16,358(1):97-100.
  DOI: 10.1016/0014-5793(94)01320-z
  pubMed: 7821439

• The cephamycin biosynthetic genes pcbAB, encoding a large multidomain peptide synthetase, and pcbC of Nocardia lactamdurans are clustered together in an organization different from the same genes in Acremonium chrysogenum and Penicillium chrysogenum
  Coque JJR, Martin JF, Calzada JG, Liras P, Molecular microbiology , 1991, 5(5):1125-1133
  DOI: 10.1111/j.1365-2958.1991.tb01885.x
  

• Gene clusters for beta-lactam antibiotics and control of their expression: why have clusters evolved, and from where did they originate?
  Coque JJR, Martin JF, Calzada JG, Liras P, International Microbiology , 2006, 9:9–19
  pubMed: 16636985

  P27742 P25464 P26046 P19787 Q01757 P94873 P27743 D4D0F8 D4B197 Q2U2A1 F8JTW5

  440722