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Keanumycin A


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  • Norine ID: NOR02012
  • DOI: 10.26097/nor02012
  • Family: syringomycin
  • Synonym(s): 3; 40H C16:0 Keanumycin;
  • Activity: antimicrobial
  • Category: lipopeptide
  • Formula: C49H84ClN11O19
  • Monoisotopic mass: 1165.5633472709999 g/mol
  • Comment:
  • Source: mynorine
  • Contributor (creation): Sebastian Götze [Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute Jena e.V.]
  • Entry information:
    • status: curated - change status to non-NRP (Norine validators only)
    • last modification date: 2023-02-01 by Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
    • view all entry history
  • Type: cyclic
  • Number of monomers: 10
  • Smiles: O=C([C@H](COC([C@@]([C@H](O)CCl)([H])NC([C@@H](NC(/C(NC([C@@]([C@@H](O)C)([H])NC([C@H](CCN)NC1=O)=O)=O)=C/C)=O)[C@H](O)C(O)=O)=O)=O)NC(C[C@H](O)[C@H](O)CCCCCCCCCCCC)=O)N[C@H](CCN)C(NCC(N[C@@H]1CCO)=O)=O

  • Graph inference:



  • Monomeric composition :
    1
    Dab
    2
    OH-Asp
    3
    Gly
    4
    Ser
    5
    C16:0-OH(3.4)
    6
    4Cl-Thr
    7
    dhAbu
    8
    D-Dab
    9
    D-Hse
    10
    aThr
  • Graph representation: Dab,OH-Asp,Gly,Ser,C16:0-OH(3.4),4Cl-Thr,dhAbu,D-Dab,D-Hse,aThr @8,9 @5,6 @7,8 @4,5,7 @3 @1,3 @1,9 @2,3 @0,2 @0,6

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Pseudomonas sp. QS1027
  • gram: negative
  • synonyms:
  • taxid: 286 (view NCBI taxonomy browser)

  • Links between organisms producing the Keanumycin A: Pseudomonas sp. QS1027
  • Ecological Niche-Inspired Genome Mining Leads to the Discovery of Crop-Protecting Nonribosomal Lipopeptides Featuring a Transient Amino Acid Building Block
    Christian Hertweck, Sebastian Götze, Pierre Stallforth, Raghav Vij, Katja Burow, Nicola Thome, Lennart Urbat, Nicolas Schlosser, Sebastian Pflanze, Rita Müller, Veit G. Hänsch, Kevin Schlabach, Leila Fazlikhani, Grit Walther, Hans-Martin Dahse, Lars Regestein, Sascha Brunke, Bernhard Hube, Philipp Franken, Journal of the American Chemical Society , 2023, 1:1-12
    DOI: 10.1021/jacs.2c11107
    pubMed: 36669196


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