Norine

• Norine ID: NOR01127
• DOI: 10.26097/nor01127
• Family: quinomycin
• Synonym(s): quinomycin B;
• Activity: antimicrobial, antitumor
• Category: peptide
• Formula: C53H68N12O12S2
• Monoisotopic mass: 1128.4521071000001 g/mol
• Comment: Quinomycins contain a thioacetal cross bridge. In the tiostin analogues, a disulfide bond replaces the thioacetal cross-link.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2020-04-29 by Maude Pupin [Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
  • view all entry history

• Type: double cyclic
• Number of monomers: 10
• Smiles: CCC(C)C1C(=O)OCC(C(=O)NC(C(=O)N(C2C(SCC(C(=O)N1C)N(C(=O)C(NC(=O)C(COC(=O)C(N(C2=O)C)C(C)CC)NC(=O)C3=NC4=CC=CC=C4N=C3)C)C)SC)C)C)NC(=O)C5=NC6=CC=CC=C6N=C5
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 COOH-Qui

  2 D-Ser

  3 Ala

  4 diMe-Cys

  5 NMe-aIle

  6 D-Ser

  7 COOH-Qui

  8 Ala

  9 NMe-Cys

  10 NMe-aIle

• Graph representation: COOH-Qui,D-Ser,Ala,diMe-Cys,NMe-aIle,D-Ser,COOH-Qui,Ala,NMe-Cys,NMe-aIle @1 @0,2,9 @1,3 @2,4,8 @3,5 @4,6,7 @5 @5,8 @3,7,9 @1,8
  
  
• Atomic structure:

vizualisation:

• Streptomyces sp.
• gram: positive
• synonyms:
• taxid: 1931 (view NCBI taxonomy browser)

• Links between organisms producing the quinomycin B: Streptomyces sp.

• Structure of quinomycin antibiotics
  Martin DG, Mizsak SA, Biles C, Stewart JC, Bacynsky L, Meulman PA, The Journal of antibiotics , 1975, Apr,28(4):332-6.
  DOI: 10.7164/antibiotics.28.332
  pubMed: 1150534

• Influence of isoleucine upon quinomycin biosynthesis by Streptomyces sp. 732.
  Journal of bacteriology , 1967, 93(4):1327-31
  pubMed: 6032510

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