Norine

• Norine ID: NOR00964
• DOI: 10.26097/nor00964
• Family: bergofungin
• Synonym(s):
• Activity: antimicrobial
• Category: peptaibol
• Formula: C73H120N16O19
• Monoisotopic mass: 1524.8915657379998 g/mol
• Comment:
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: linear
• Number of monomers: 15
• Smiles: CC[C@@](C)(C(=O)N1C[C@@H](C[C@H]1C(=O)NC(C)(C)C(=O)N[C@@H](CC2=CC=CC=C2)CO)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]3C[C@H](CN3C(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](C(C)C)NC(=O)C)O
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Ac-Val	2 Aib	3 Aib	4 Aib	5 Val	6 Gly	7 Leu	8 Aib	9 Aib	10 4OH-Pro	11 Gln	12 Ival
  13 4OH-Pro	14 Aib	15 Pheol

• Graph representation: Ac-Val,Aib,Aib,Aib,Val,Gly,Leu,Aib,Aib,4OH-Pro,Gln,Ival,4OH-Pro,Aib,Pheol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13
  
  
• Atomic structure:

vizualisation:

• Emericellopsis donezkii
• gram:
• synonyms:
• taxid: 281368 (view NCBI taxonomy browser)

• Links between organisms producing the bergofungin A: Emericellopsis donezkii

• Isolation and structure of bergofungin, a new antifungal peptaibol from Emericellopsis donezkii HKI 0059
  Ritzau M, Heinze S, Berg A, Schlegel B, Grafe U, Ihn W, Fleck WF, The Journal of antibiotics , 1996, Aug,49(8):817-20.
  DOI: 10.7164/antibiotics.49.817
  pubMed: 8823517

• A natural, single-residue substitution yields a less active peptaibiotic: the structure of bergofungin A at atomic resolution.
  R. Gessmann, D. Axford, H. Brückner, A. Berg and K. Petratos, Acta Crystallographica. Section F, Structural Biology Communications , 2017, 73:95-100
  DOI: 10.1107/S2053230X17001236
  pubMed: 28177320

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