Norine

• Norine ID: NOR00342
• DOI: 10.26097/nor00342
• Family: amphisin
• Synonym(s): anikasin;
• Activity: antimicrobial, surfactant
• Category: lipopeptide
• Formula: C63H109N11O20
• Monoisotopic mass: 1339.785034983 g/mol
• Comment: Anikasin is a synonymous of lokisin. Only anikasin structure was experimentally elucidated.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2019-02-20 by Sebastian Götze [University Koblenz-Landau Faculty 7: Natural and Environmental Sciences]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 12
• Smiles: CCCCCCC[C@H](CC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H]1[C@H](OC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(C)C)CC(C)C)CO)CC(C)C)CO)CC(C)C)[C@H](C)CC)CC(=O)O)C)O
  
  
• Graph inference:


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• Monomeric composition :

  1 C10:0-OH(3)	2 D-Leu	3 D-Asp	4 D-aThr	5 D-Leu	6 D-Leu	7 D-Ser	8 Leu	9 D-Ser	10 Leu	11 Ile	12 Asp

• Graph representation: C10:0-OH(3),D-Leu,D-Asp,D-aThr,D-Leu,D-Leu,D-Ser,Leu,D-Ser,Leu,Ile,Asp @1 @0,2 @1,3 @2,4,11 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @3,10
  
  
• Atomic structure:

vizualisation:

• Pseudomonas sp. DSS41
• gram: negative
• synonyms:
• taxid: (view NCBI taxonomy browser)

• Pseudomonas fluorescens HKI0770
• gram: negative
• synonyms:
• taxid: 658629 (view NCBI taxonomy browser)

• Links between organisms producing the lokisin: Pseudomonas sp. DSS41, Pseudomonas fluorescens HKI0770

• Cyclic lipoundecapeptide lokisin from Pseudomonas sp. strain DSS41
  Nielsen TH, Christophersen C, Sorensen J, Sorensen D, Tetrahedron letters , 2002, 43 4421-4423.
  

• Structure, Biosynthesis, and Biological Activity of the Cyclic Lipopeptide Anikasin
  Götze S, Klapper M, Stallforth P, Herbst-Irmer R, Görls H, Schneider KRA, Barnett R, Burks T, Neu U, ACS Chemical Biology , 2017, 12:2498-2502
  DOI: 10.1021/acschembio.7b00589
  pubMed: 28846366