A54145 A1
- Norine ID: NOR00714
- DOI: 10.26097/nor00714
- Family: A54145
- Synonym(s): A54145 A1;
- Activity: antimicrobial
- Category: lipopeptide
- Formula: C72H109N17O27
- Monoisotopic mass: 1643.767881367 g/mol
- Comment: A54145 products are antibiotics for the traitment of infections caused by gram-positive pathogens.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- view all entry history
- Type: partial cyclic
- Number of monomers: 14
- Monomeric composition :
1 C10:0 2 Trp 3 D-Glu 4 OH-Asn 5 Thr 6 NMe-Gly 7 Ala 8 Asp 9 D-Lys 10 OMe-Asp 11 Gly 12 D-Asn 13 Glu 14 Ile - Graph representation: C10:0,Trp,D-Glu,OH-Asn,Thr,NMe-Gly,Ala,Asp,D-Lys,OMe-Asp,Gly,D-Asn,Glu,Ile @1 @0,2 @1,3 @2,4 @3,5,13 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @4,12
- Atomic structure:
Peptide's atomic structure image is not available because smiles is not present.
- Streptomyces fradiae
- gram: positive
- synonyms: Streptomyces roseoflavus,Streptomyces fradii,Actinomyces fradii,Streptomyces roseiflavus
- taxid: 1906 (view NCBI taxonomy browser)
- Links between organisms producing the A54145 A1: Streptomyces fradiae
- The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae
Baltz RH, Miao V, Brost R, Chapple J, She K, Gal MF, Journal of industrial microbiology and biotechnology , 2006, Feb,33(2):129-40. Epub 2005 Oct 6.
DOI: 10.1007/s10295-005-0028-5
pubMed: 16208464
- Natural products to drugs: daptomycin and related lipopeptide antibiotics
Baltz RH, Miao V, Wrigley SK, Natural product reports , 2005, Dec,22(6):717-41. Epub 2005 Nov 4.
DOI: 10.1039/b416648p
pubMed: 16311632
- Biosynthesis and genetic engineering of lipopeptide antibiotics related to daptomycin
Baltz RH, Current topics in medicinal chemistry , 2008, 8(8):618-38
DOI: 10.2174/156802608784221497
pubMed: 18473888
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