polydiscamide B
- Norine ID: NOR00840
- DOI: 10.26097/nor00840
- Family: polydiscamide
- Synonym(s): polydiscamide B;
- Activity: antiinflammatory
- Category: peptide
- Formula: C75H110BrN18O21S
- Monoisotopic mass: 1709.6997013720002 g/mol
- Comment: Polydiscamides are putative NRPS products (no synthetase genes identified).
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: putative - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: partial cyclic
- Number of monomers: 13
- Smiles: CCC(C)(C)C(NC(=O)C(NC(=O)C2CCCN2(C(=O)C(Cc1ccc(cc1)Br)NC(=O)C(C)NC=O))C(C)(C)C)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NC(CCCN=C(N)N)C(=O)NC(CS(=O)(=O)O)C(=O)NC5C(C)OC(=O)C(CC(=O)O)NC(=O)C6CCCN6(C(=O)C(NC(=O)C(CCC(N)=O)N(C)C5(=O))C(C)C)
- Graph inference:
- Monomeric composition :
1 D-NFo-Ala 2 Br-Phe 3 Pro 4 D-t-Leu 5 bMe-Ile 6 D-Trp 7 Arg 8 D-CysA 9 Thr 10 NMe-Gln 11 D-Val 12 Pro 13 D-Asp - Graph representation: D-NFo-Ala,Br-Phe,Pro,D-t-Leu,bMe-Ile,D-Trp,Arg,D-CysA,Thr,NMe-Gln,D-Val,Pro,D-Asp @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9,12 @8,10 @9,11 @10,12 @8,11
- Atomic structure:
- Ircinia
- taxid: 275431 (view NCBI taxonomy browser)
- Links between organisms producing the polydiscamide B: Ircinia
- Polydiscamides B-D from a marine sponge Ircinia sp. as potent human sensory neuron-specific G protein coupled receptor agonists
Feng Y, Carroll AR, Pass DM, Archbold JK, Avery VM, Quinn RJ, Journal of natural products , 2008, Jan,71(1):8-11.
DOI: 10.1021/np070094r
pubMed: 18163586
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