fengycin A
- Norine ID: NOR00226
- DOI: 10.26097/nor00226
- Family: fengycin
- Synonym(s): fengycin A;
- Activity: antimicrobial, surfactant
- Category: lipopeptide
- Formula: C72H110N12O20
- Monoisotopic mass: 1462.79593402 g/mol
- Comment: The lipid moiety of both analogs is more variable, as fatty acids have been identified as anteiso-pentadecanoic acid (ai-C15), iso-hexadecanoic acid (i-C16), n-hexadecanoic acid (n-C16), and there is evidence for further saturated and unsaturated residues up to C18.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: partial cyclic
- Number of monomers: 11
- Smiles: CCCCCCCCCCCCCC(O)CC(=O)NC(CCC(=O)O)C(=O)NC(CCCN)C(=O)NC3Cc1ccc(cc1)OC(=O)C(NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(CCC(N)=O)NC(=O)C4CCCN4(C(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(NC3(=O))C(C)O))C(C)CC
- Graph inference:
- Monomeric composition :
1 C16:0-OH(3) 2 Glu 3 D-Orn 4 Tyr 5 D-aThr 6 Glu 7 D-Ala 8 Pro 9 Gln 10 D-Tyr 11 Ile - Graph representation: C16:0-OH(3),Glu,D-Orn,Tyr,D-aThr,Glu,D-Ala,Pro,Gln,D-Tyr,Ile @1 @0,2 @1,3 @2,4,10 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @3,9
- Atomic structure:
- Bacillus subtilis
- gram: positive
- synonyms: Bacillus uniflagellatus,Bacillus natto,Bacillus globigii,Vibrio subtilis
- taxid: 1423 (view NCBI taxonomy browser)
- Links between organisms producing the fengycin A: Bacillus subtilis
- Fengycin, a novel antifungal lipopeptide antibiotic produced by Bacillus subtilis F-29-3
Vanittanakom N, Loeffler W, Koch U, Jung G, The Journal of antibiotics , 1986, Jul,39(7):888-901.
DOI: 10.7164/antibiotics.39.888
pubMed: 3093430
- Nonribosomal synthesis of fengycin on an enzyme complex formed by fengycin synthetases
Wu CY, Chen CL, Lee YH, Cheng YC, Wu YC, Shu HY, Gotz F, Liu ST, The Journal of biological chemistry , 2007, Feb 23,282(8):5608-16.
DOI: 10.1074/jbc.M609726200
pubMed: 17182617
Return to annotations search