gramicidin S
- Norine ID: NOR00249
- DOI: 10.26097/nor00249
- Family: gramicidin
- Synonym(s): gramicidin S;
- Activity: antimicrobial
- Category: peptide
- Formula: C60H92N12O10
- Monoisotopic mass: 1140.705937224 g/mol
- Comment: It is a decapeptide which forms a cylic beta-sheet conformation , consisting of two antiparallel beta-strands connected by type II-turns.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: cyclic
- Number of monomers: 10
- Smiles: CC(C)CC3NC(=O)C(CCCN)NC(=O)C(NC(=O)C5CCCN5(C(=O)C(Cc1ccccc1)NC(=O)C(CC(C)C)NC(=O)C(CCCN)NC(=O)C(NC(=O)C4CCCN4(C(=O)C(Cc2ccccc2)NC3(=O)))C(C)C))C(C)C
- Graph inference:
- Monomeric composition :
1 Val 2 Orn 3 Leu 4 D-Phe 5 Pro 6 Val 7 Orn 8 Leu 9 D-Phe 10 Pro - Graph representation: Val,Orn,Leu,D-Phe,Pro,Val,Orn,Leu,D-Phe,Pro @1,9 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @0,8
- Atomic structure:
- Bacillus brevis
- gram: positive
- synonyms: Brevibacillus brevis
- taxid: 1393 (view NCBI taxonomy browser)
- Links between organisms producing the gramicidin S: Bacillus brevis
- Substrate recognition and selection by the initiation module PheATE of gramicidin S synthetase
Luo L, Burkart MD, Stachelhaus T, Walsh CT, Journal of the American Chemical Society , 2001, Nov 14,123(45):11208-18.
DOI: 10.1021/ja0166646
pubMed: 11697963
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