Norine

• Norine ID: NOR00339
• DOI: 10.26097/nor00339
• Family: amphisin
• Synonym(s): amphisin;
• Activity: surfactant, antimicrobial
• Category: lipopeptide
• Formula: C66H114N12O20
• Monoisotopic mass: 1394.8272341480001 g/mol
• Comment: Amphisin is a close analogue of the cyclic lipopeptides tensin and pholipeptin produced by Pseudomonas fluorescens.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 12
• Smiles: CCCCCCC[C@H](CC(=O)N[C@H](CC(C)C)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H]1[C@H](OC(=O)[C@@H](NC(=O)[C@H](NC(=O)C(NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(C)C)CC(C)C)CO)CC(C)C)CCC(=O)N)CC(C)C)[C@H](C)CC)CC(=O)O)C)O
  
  
• Graph inference:


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• Monomeric composition :

  1 C10:0-OH(3)	2 D-Leu	3 D-Asp	4 D-aThr	5 D-Leu	6 D-Leu	7 D-Ser	8 Leu	9 D-Gln	10 Leu	11 Ile	12 Asp

• Graph representation: C10:0-OH(3),D-Leu,D-Asp,D-aThr,D-Leu,D-Leu,D-Ser,Leu,D-Gln,Leu,Ile,Asp @1 @0,2 @1,3 @2,4,11 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @3,10
  
  
• Atomic structure:

vizualisation:

• Pseudomonas sp. DSS73
• gram: negative
• taxid: 173677 (view NCBI taxonomy browser)

• Links between organisms producing the amphisin: Pseudomonas sp. DSS73

• Cyclic lipoundecapeptide amphisin from Pseudomonas sp. strain DSS73
  Nielsen TH, Christophersen C, Sorensen J, Sorensen D, Gajhede M, Acta crystallographica. Section C, Crystal structure communications , 2001, Sep,57(Pt 9):1123-4. Epub 2001 Sep 11
  DOI: 10.1107/s0108270101010782
  pubMed: 11588392

• Genes involved in cyclic lipopeptide production are important for seed and straw colonization by Pseudomonas sp. strain DSS73
  Nielsen TH, Nybroe O, Koch B, Hansen M, Sorensen J, Applied and environmental microbiology , 2005, Jul,71(7):4112-6.
  DOI: 10.1128/AEM.71.7.4112-4116.2005
  pubMed: 16000829

  Q936V0