Norine

• Norine ID: NOR00640
• DOI: 10.26097/nor00640
• Family: capreomycin
• Synonym(s): capreomycin IIA;
• Activity: antimicrobial
• Category: peptide
• Formula: C19H32N12O7
• Monoisotopic mass: 540.251691438 g/mol
• Comment: The tuberactinomycin antibiotics are essential components in the drug arsenal against Mycobacterium tuberculosis infections and are specifically used for the treatment of multidrug-resistant tuberculosis.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 5
• Smiles: NCC1NC(=O)C(CO)NC(=O)C(N)CNC(=O)C(NC(=O)C(=CNC(N)=O)NC1(=O))C2CCN=C(N)N2
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Dpr

  2 bU-dAla

  3 Cap

  4 Dpr

  5 Ser

• Graph representation: Dpr,bU-dAla,Cap,Dpr,Ser @1,4 @0,2 @1,3 @2,4 @0,3
  
  
• Atomic structure:

vizualisation:

• Streptomyces
• gram: positive
• synonyms: Chainia
• taxid: 1883 (view NCBI taxonomy browser)

• Links between organisms producing the capreomycin IIA: Streptomyces

• Deciphering tuberactinomycin biosynthesis: isolation, sequencing, and annotation of the viomycin biosynthetic gene cluster
  Thomas MG, Chan YA, Ozanick SG, Antimicrobial agents and chemotherapy , 2003, Sep,47(9):2823-30.
  DOI: 10.1128/aac.47.9.2823-2830.2003
  pubMed: 12936980

• Identification of the biosynthetic gene cluster and an additional gene for resistance to the antituberculosis drug capreomycin
  Thomas MG, Berti AD, Felnagle EA, Rondon MR, Crosby HA, Applied and environmental microbiology , 2007, Jul,73(13):4162-70. Epub 2007 May 11.
  DOI: 10.1128/AEM.00485-07
  pubMed: 17496129

  A6YEH2 A6YEH7 A6YEH8 A6YEI6 A6YEI0 A6YEI4

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