Norine

• Norine ID: NOR00633
• DOI: 10.26097/nor00633
• Family: tuberactinomycin
• Synonym(s): viomycin;
• Activity: antimicrobial
• Category: peptide
• Formula: C25H43N13O10
• Monoisotopic mass: 685.325584661 g/mol
• Comment: The tuberactinomycin antibiotics are essential components in the drug arsenal against Mycobacterium tuberculosis infections and are specifically used for the treatment of multidrug-resistant tuberculosis.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 6
• Smiles: NCCCC(N)CC(=O)NC1CNC(=O)C(NC(=O)C(=CNC(N)=O)NC(=O)C(CO)NC(=O)C(CO)NC1(=O))C2CC(O)N=C(N)N2
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 bLys

  2 Dpr

  3 Ser

  4 Ser

  5 bU-dAla

  6 5OH-Cap

• Graph representation: bLys,Dpr,Ser,Ser,bU-dAla,5OH-Cap @1 @0,2,5 @1,3 @2,4 @3,5 @1,4
  
  
• Atomic structure:

vizualisation:

• Streptomyces
• gram: positive
• synonyms: Chainia
• taxid: 1883 (view NCBI taxonomy browser)

• Streptomyces puniceus
• gram: positive
• taxid: 67351 (view NCBI taxonomy browser)

• Links between organisms producing the viomycin: Streptomyces, Streptomyces puniceus

• Deciphering tuberactinomycin biosynthesis: isolation, sequencing, and annotation of the viomycin biosynthetic gene cluster
  Thomas MG, Chan YA, Ozanick SG, Antimicrobial agents and chemotherapy , 2003, Sep,47(9):2823-30.
  DOI: 10.1128/aac.47.9.2823-2830.2003
  pubMed: 12936980

  Q6WZ98 Q6WZA0 Q6WZA4 Q6WZA7 Q6WZB2 Q84CG4

  3037981

  CHEMBL3085436

  3knj 3knh

  3knj 3knh

  3knj 3knh