Norine

• Norine ID: NOR00036
• DOI: 10.26097/nor00036
• Family: cyclosporin
• Synonym(s): cyclosporin D;
• Activity: immunomodulating, antimicrobial
• Category: peptide
• Formula: C63H113N11O12
• Monoisotopic mass: 1215.857018135 g/mol
• Comment: Natural analogs of cyclosporin A are obtain in different nutrient broths
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France, Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 11
• Smiles: CC=CCC(C)C(O)C1C(=O)NC(C(C)C)C(=O)N(C)CC(=O)N(C)C(CC(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(C(C)C)C(=O)N1(C)
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 D-Ala

  2 NMe-Leu

  3 NMe-Leu

  4 NMe-Val

  5 NMe-Bmt

  6 Val

  7 NMe-Gly

  8 NMe-Leu

  9 Val

  10 NMe-Leu

  11 Ala

• Graph representation: D-Ala,NMe-Leu,NMe-Leu,NMe-Val,NMe-Bmt,Val,NMe-Gly,NMe-Leu,Val,NMe-Leu,Ala @1,10 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @0,9
  
  
• Atomic structure:

vizualisation:

• Tolypocladium inflatum
• gram:
• synonyms: Tolypocladium niveum,Beauveria nivea
• taxid: 29910 (view NCBI taxonomy browser)

• Links between organisms producing the cyclosporin D: Tolypocladium inflatum

• Multifunctional Peptide Synthetases
  von Dohren H, Keller U, Vater J, Zocher R, Chemical reviews , 1997, Nov 10,97(7):2675-2706.
  pubMed: 11851477

  Q09164

  6436250