Norine

• Norine ID: NOR00021
• DOI: 10.26097/nor00021
• Family: bacitracin
• Synonym(s): bacitracin B3;
• Activity: antimicrobial
• Category: peptide
• Formula: C65H101N17O16S
• Monoisotopic mass: 1407.7332909689999 g/mol
• Comment: Bacitracin is a mixture a many similar compounds. The major compound is the bacitracin A1.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: other
• Number of monomers: 12
• Smiles: CC[C@H](C)[C@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)NCCCC[C@@H](C(=O)N[C@@H](C(=O)N1)CCCN)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CSC(=N2)[C@H](C(C)C)N)CC(=O)N)CC(=O)O)CC3=CN=CN3)CC4=CC=CC=C4
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition :

  1 Ile	2 Cys	3 Leu	4 D-Glu	5 Ile	6 Lys	7 D-Orn	8 Val	9 D-Phe	10 His	11 D-Asp	12 Asn

• Graph representation: Ile,Cys,Leu,D-Glu,Ile,Lys,D-Orn,Val,D-Phe,His,D-Asp,Asn @1,1 @0,0,2 @1,3 @2,4 @3,5 @4,6,11 @5,7 @6,8 @7,9 @8,10 @9,11 @5,10
  
  
• Atomic structure:

vizualisation:

• Bacillus licheniformis
• gram: positive
• synonyms: Denitrobacillus licheniformis,Clostridium licheniforme
• taxid: 1402 (view NCBI taxonomy browser)

• Bacillus subtilis
• gram: positive
• synonyms: Bacillus uniflagellatus,Bacillus natto,Bacillus globigii,Vibrio subtilis
• taxid: 1423 (view NCBI taxonomy browser)

• Links between organisms producing the bacitracin B3: Bacillus licheniformis, Bacillus subtilis

• Proton NMR studies of Co(II) complexes of the peptide antibiotic bacitracin and analogues: insight into structure-activity relationship
  Epperson JD, Ming LJ, Biochemistry , 2000, Apr 11,39(14):4037-45.
  DOI: 10.1021/bi991997p
  pubMed: 10747792

• The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases
  Marahiel MA, Konz D, Klens A, Schorgendorfer K, Chemistry and biology , 1997, Dec,4(12):927-37.
  pubMed: 9427658

  O68006 O68007 O68008