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ampullosporin A


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  • Norine ID: NOR00937
  • DOI: 10.26097/nor00937
  • Family: ampullosporin
  • Synonym(s): ampullosporin A;
  • Activity: antimicrobial
  • Category: peptaibol
  • Formula: C77H127N19O19
  • Monoisotopic mass: 1621.9555629769998 g/mol
  • Comment: Ampullosporin displays narrow-spectrum antibacterial and antifungal activity, induces pigment formation by Phoma destructiva, causes hypothermia and decreased spontaneous locomotor activity in mice.
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: linear
  • Number of monomers: 15
  • Smiles: C[C@@H](C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](CCC(=O)N)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)CO)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)C

  • Graph inference:



  • Monomeric composition :
    1
    Ac-Trp
    2
    Ala
    3
    Aib
    4
    Aib
    5
    Leu
    6
    Aib
    7
    Gln
    8
    Aib
    9
    Aib
    10
    Aib
    11
    Gln
    12
    Leu
    13
    Aib
    14
    Gln
    15
    Leuol
  • Graph representation: Ac-Trp,Ala,Aib,Aib,Leu,Aib,Gln,Aib,Aib,Aib,Gln,Leu,Aib,Gln,Leuol @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @10,12 @11,13 @12,14 @13

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Sepedonium ampullosporum
  • taxid: 74838 (view NCBI taxonomy browser)

  • Links between organisms producing the ampullosporin A: Sepedonium ampullosporum
  • A nonribosomal peptide synthetase involved in the biosynthesis of ampullosporins in Sepedonium ampullosporum
    Reiber K, Neuhof T, Ozegowski JH, von Dohrend H, Schwecke T, Journal of peptide science , 2003, Nov-Dec,9(11-12):701-13.
    DOI: 10.1002/psc.529
    pubMed: 14658790
  • Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice
    Ritzau M, Heinze S, Dornberger K, Berg A, Fleck W, Schlegel B, Hartl A, Grafe U, The Journal of antibiotics , 1997, Sep,50(9):722-8.
    DOI: 10.7164/antibiotics.50.722
    pubMed: 9360615


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