Norine

• Norine ID: NOR00301
• DOI: 10.26097/nor00301
• Family: tyrocidine
• Synonym(s): tyrocidine D;
• Activity: antimicrobial
• Category: peptide
• Formula: C72H90N16O12
• Monoisotopic mass: 1370.6924124240002 g/mol
• Comment: Tyrocidine kills bacteria by interacting with their cytoplasmic membrane and causing leakage of their intracellular content. It also affects intracellular membranes such as those of mitochondria.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: cyclic
• Number of monomers: 10
• Smiles: CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN)C(C)C)CC3=CNC4=CC=CC=C43)CCC(=O)N)CC(=O)N)CC5=CNC6=CC=CC=C65)CC7=CNC8=CC=CC=C87)CC9=CC=CC=C9
  
  
• Graph inference:


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• Monomeric composition :

  1 D-Phe

  2 Pro

  3 Trp

  4 D-Trp

  5 Asn

  6 Gln

  7 Trp

  8 Val

  9 Orn

  10 Leu

• Graph representation: D-Phe,Pro,Trp,D-Trp,Asn,Gln,Trp,Val,Orn,Leu @1,9 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @0,8
  
  
• Atomic structure:

vizualisation:

• Bacillus brevis
• gram: positive
• synonyms: Brevibacillus brevis
• taxid: 1393 (view NCBI taxonomy browser)

• Links between organisms producing the tyrocidine D: Bacillus brevis

• The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
  Mootz HD, Marahiel MA, Journal of bacteriology , 1997, Nov,179(21):6843-50.
  DOI: 10.1128/jb.179.21.6843-6850.1997
  pubMed: 9352938

  P09095 O30408 O30409