discodermin A
- Norine ID: NOR00447
- DOI: 10.26097/nor00447
- Family: discodermin
- Synonym(s): discodermin A;
- Activity: antitumor, antimicrobial, toxin
- Category: peptide
- Formula: C77H115N20O22S
- Monoisotopic mass: 1703.821551164 g/mol
- Comment: Discodermin A is a putative NRPS product (no synthetase genes identified).
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: putative - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: partial cyclic
- Number of monomers: 14
- Smiles: CC(C)CC1NC(=O)C(CCC(N)=O)N(C)C(=O)C(NC(=O)C(CS(O)(=O)=O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC2=CNC3=CC=CC=C23)NC(=O)C(NC(=O)C(NC(=O)C2CCCN2C(=O)C(CC2=CC=CC=C2)NC(=O)C(C)NC=O)C(C)(C)C)C(C)(C)C)C(C)OC(=O)CN(C)C(=O)C(CC(N)=O)NC(=O)C(NC1=O)C(C)O
- Graph inference:
- Monomeric composition :
1 D-NFo-Ala 2 Phe 3 Pro 4 D-t-Leu 5 t-Leu 6 D-Trp 7 Arg 8 D-CysA 9 Thr 10 NMe-Gln 11 D-Leu 12 Thr 13 Asn 14 NMe-Gly - Graph representation: D-NFo-Ala,Phe,Pro,D-t-Leu,t-Leu,D-Trp,Arg,D-CysA,Thr,NMe-Gln,D-Leu,Thr,Asn,NMe-Gly @1 @0,2 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9,13 @8,10 @9,11 @10,12 @11,13 @8,12
- Atomic structure:
- Discodermia kiiensis
- gram:
- synonyms:
- taxid: (view NCBI taxonomy browser)
- Links between organisms producing the discodermin A: Discodermia kiiensis
- Membrane permeabilization induced by discodermin A, a novel marine bioactive peptide
Matsunaga S, Fusetani N, Sato K, Horibe K, Amano K, Mitusi-Saito M, Hori M, Ozaki H, Karaki H, Toxicon : official journal of the International Society on Toxinology , 2001, Feb-Mar,39(2-3):259-64.
DOI: 10.1016/s0041-0101(00)00123-9
pubMed: 10978743
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