kapakahine B
- Norine ID: NOR00481
- DOI: 10.26097/nor00481
- Family: kapakahine
- Synonym(s): kapakahine B;
- Activity: antitumor, toxin
- Category: peptide
- Formula: C49H52N8O6
- Monoisotopic mass: 848.4009814359999 g/mol
- Comment: Kapakahines share a unique structural feature: two tryptophan residues (Trp-1 and -2) are not linked by an amide bond but by a N-C bond from the indole nitrogen of Trp-1 to the indole carbon of Trp-2.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: putative - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: other
- Number of monomers: 6
- Smiles: C[C@H]1C(=O)N[C@H](C(=O)N[C@H]2C[C@@]3([C@@H]4N(C2=O)[C@H](C(=O)N4C5=CC=CC=C53)CC6=CC=CC=C6)N7C=C(C[C@@H](C(=O)N1)NC(=O)[C@H](CC8=CC=CC=C8)N)C9=CC=CC=C97)CC(C)C
- Graph inference:
- Monomeric composition :
1 Phe 2 Trp 3 Ala 4 Leu 5 Trp 6 Phe - Graph representation: Phe,Trp,Ala,Leu,Trp,Phe @1,1 @0,0,2,4 @1,3 @2,4 @1,3,5 @4
- Atomic structure:
- Cribrochalina olemda
- Links between organisms producing the kapakahine B: Cribrochalina olemda
- The Kapakahines, Cyclic Peptides from the Marine Sponge Cribrochalina olemda
Scheuer PJ, Nakao Y, Yoshida WY, Yeung BK, Kinnel RB, Carney JR, Kelly-Borges M, The Journal of organic chemistry , 1996, Oct 4,61(20):7168-7173.
DOI: 10.1021/jo960725e
pubMed: 11667621
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