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haligramide B


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  • Norine ID: NOR00577
  • DOI: 10.26097/nor00577
  • Family: haligramide
  • Synonym(s): haligramide B;
  • Activity: antitumor, toxin
  • Category: peptide
  • Formula: C37H49N7O7S3
  • Monoisotopic mass: 799.285559057 g/mol
  • Comment: haligramides are putative NRPS products (no synthetase genes identified)
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: cyclic
  • Number of monomers: 6
  • Smiles: CSCCC3NC(=O)C6CCCN6(C(=O)C5CCCN5(C(=O)C(CCS(C)=O)NC(=O)c1csc(n1)C(Cc2ccccc2)NC(=O)C4CCCN4(C3(=O))))

  • Graph inference:



  • Monomeric composition :
    1
    O-Met
    2
    Phe-Thz
    3
    Pro
    4
    Met
    5
    Pro
    6
    Pro
  • Graph representation: O-Met,Phe-Thz,Pro,Met,Pro,Pro @1,5 @0,2 @1,3 @2,4 @3,5 @0,4

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Haliclona nigra

  • Links between organisms producing the haligramide B: Haliclona nigra
  • Haligramides A and B, two new cytotoxic hexapeptides from the marine sponge Haliclona nigra
    Rashid MA, Gustafson KR, Boyd MR, Boswell JL, Journal of natural products , 2000, Jul,63(7):956-9.
    DOI: 10.1021/np000051+
    pubMed: 10924173


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