jaspamide
- Norine ID: NOR00329
- DOI: 10.26097/nor00329
- Family: jaspamide
- Synonym(s): jaspamide;
- Activity: antimicrobial, antitumor
- Category: peptide
- Formula: C36H45BrN4O6
- Monoisotopic mass: 708.252248192 g/mol
- Comment: Jaspamide showed ability to interact with actin filaments and in particular to produce structural and biophysical changes of cytoskeletal dynamics, resulting in a potent antiproliferative activity.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: cyclic
- Number of monomers: 4
- Smiles: CC3C=C(C)CC(C)C(=O)NC(C)C(=O)N(C)C(Cc1c2ccccc2([nH]c1Br))C(=O)NC(CC(=O)OC(C)C3)c4ccc(O)cc4
- Graph inference:
- Monomeric composition :
1 C9:1(4)-Me(2.4.6)-OH(8) 2 Ala 3 NMe-Br-Trp 4 bTyr - Graph representation: C9:1(4)-Me(2.4.6)-OH(8),Ala,NMe-Br-Trp,bTyr @1,3 @0,2 @1,3 @0,2
- Atomic structure:
- jaspis sp.
- Auletta sp.
- hemiasterella minor
- Links between organisms producing the jaspamide: jaspis sp., Auletta sp., hemiasterella minor
- Jaspamide, a modified peptide from a Jaspis sponge, with insecticidal and antifungal activity
Zabriskie TM, Klocke JA, Ireland CM, Journal of the American Chemical Society , 1986, 108 (11), pp. 3123-3124
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