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CDA3a


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  • Norine ID: NOR00026
  • DOI: 10.26097/nor00026
  • Family: Calcium dependent antibiotic
  • Synonym(s): CDA3a;
  • Activity: antimicrobial
  • Category: lipopeptide
  • Formula: C66H76N14O26
  • Monoisotopic mass: 1480.505518674 g/mol
  • Comment: CDA shares a similar structure and possibly a related mode of action to other acidic lipopeptide antibiotics, including daptomycin, friulimicins, and amphomycins.
  • Source: norine
  • Contributor (creation): Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • Entry information:
  • Type: partial cyclic
  • Number of monomers: 12
  • Monomeric composition :
    1
    C6:0-Ep(2)
    2
    Ser
    3
    Thr
    4
    D-Trp
    5
    Asp
    6
    Asp
    7
    D-Hpg
    8
    Asp
    9
    Gly
    10
    D-OH-Asn
    11
    Glu
    12
    dh-Trp
  • Graph representation: C6:0-Ep(2),Ser,Thr,D-Trp,Asp,Asp,D-Hpg,Asp,Gly,D-OH-Asn,Glu,dh-Trp @1 @0,2 @1,3,11 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @2,10

  • Atomic structure:

    • Peptide's atomic structure image is not available because smiles is not present.

  • Trichothecium roseum
  • gram:
  • synonyms:
  • taxid: 47278 (view NCBI taxonomy browser)

  • Streptomyces roseosporus
  • gram: positive
  • synonyms: Streptomyces filamentosus,Streptomyces venezuelae subsp. roseospori,Streptomyces roseisporus
  • taxid: 67294 (view NCBI taxonomy browser)

  • Streptomyces coelicolor
  • gram: positive
  • synonyms: Actinomyces coelicolor,Nocardia coelicolor,Cladothrix coelicolor,Streptothrix coelicolor
  • taxid: 1902 (view NCBI taxonomy browser)

  • Links between organisms producing the CDA3a: Trichothecium roseum, Streptomyces roseosporus, Streptomyces coelicolor
  • Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor
    Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J, Chemistry and biology , 2002, Nov,9(11):1175-87.
    pubMed: 12445768


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