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axinastatin 3


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  • Norine ID: NOR00517
  • DOI: 10.26097/nor00517
  • Family: axinastatin
  • Synonym(s): axinastatin 3;
  • Activity: antitumor, toxin
  • Category: peptide
  • Formula: C40H60N8O8
  • Monoisotopic mass: 780.453410936 g/mol
  • Comment: axinastatin is a putative NRPS product (no synthetase genes identified)
  • Source: norine
  • Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
  • Entry information:
  • Type: cyclic
  • Number of monomers: 7
  • Smiles: CCC(C)C2NC(=O)C(Cc1ccccc1)NC(=O)C4CCCN4(C(=O)C(CC(N)=O)NC(=O)C(NC(=O)C3CCCN3(C(=O)C(CC(C)C)NC2(=O)))C(C)C)

  • Graph inference:



  • Monomeric composition :
    1
    Pro
    2
    Phe
    3
    Ile
    4
    Leu
    5
    Pro
    6
    Val
    7
    Asn
  • Graph representation: Pro,Phe,Ile,Leu,Pro,Val,Asn @1,6 @0,2 @1,3 @2,4 @3,5 @4,6 @0,5

  • Atomic structure:
    • Chemical structure
    rBAN vizualisation:
  • Axinella
  • taxid: 12958 (view NCBI taxonomy browser)

  • Links between organisms producing the axinastatin 3: Axinella
  • Antineoplastic agents. 278. Isolation and structure of axinastatins 2 and 3 from a western Caroline Island marine sponge
    Pettit GR, Gao F, Cerny RL, Doubek DL, Tackett LP, Schmidt JM, Chapuis JC, Journal of medicinal chemistry , 1994, Apr 15,37(8):1165-8.
    DOI: 10.1021/jm00034a014
    pubMed: 8164258


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