Norine

• Norine ID: NOR00916
• DOI: 10.26097/nor00916
• Family: bacitracin
• Synonym(s): bacitracin B1;
• Activity: antimicrobial
• Category: peptide
• Formula: C65H101N17O16S
• Monoisotopic mass: 1407.7332909689999 g/mol
• Comment: Bacitracin is a mixture a many similar compounds. The major compound is the bacitracin A1.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: other
• Number of monomers: 12
• Smiles: CC[C@H](C)[C@@H](C1=N[C@@H](CS1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CCCCNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC2=O)CCCN)C(C)C)CC3=CC=CC=C3)CC4=CN=CN4)CC(=O)O)CC(=O)N)N
  
  
• Graph inference:


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• Monomeric composition :

  1 Val	2 Cys	3 Leu	4 D-Glu	5 Ile	6 Lys	7 D-Orn	8 Ile	9 D-Phe	10 His	11 D-Asp	12 Asn

• Graph representation: Val,Cys,Leu,D-Glu,Ile,Lys,D-Orn,Ile,D-Phe,His,D-Asp,Asn @1,1 @0,0,2 @1,3 @2,4 @3,5 @4,6,11 @5,7 @6,8 @7,9 @8,10 @9,11 @5,10
  
  
• Atomic structure:

vizualisation:

• Bacillus subtilis
• gram: positive
• synonyms: Bacillus uniflagellatus,Bacillus natto,Bacillus globigii,Vibrio subtilis
• taxid: 1423 (view NCBI taxonomy browser)

• Bacillus licheniformis
• gram: positive
• synonyms: Denitrobacillus licheniformis,Clostridium licheniforme
• taxid: 1402 (view NCBI taxonomy browser)

• Links between organisms producing the bacitracin B1: Bacillus subtilis, Bacillus licheniformis

• The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases
  Marahiel MA, Konz D, Klens A, Schorgendorfer K, Chemistry and biology , 1997, Dec,4(12):927-37.
  pubMed: 9427658

• Total structures and antimicrobial activity of bacitracin minor components
  Harada K, Suzuki M, Ikai Y, Oka H, Hayakawa J, Matsumoto M, Saito M, Mayumi Y, The Journal of antibiotics , 1995, Mar,48(3):233-42.
  DOI: 10.7164/antibiotics.48.233
  pubMed: 7730158

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