Norine

• Norine ID: NOR00864
• DOI: 10.26097/nor00864
• Family: syringomycin
• Synonym(s): syringomycin A1;
• Activity: antimicrobial, surfactant
• Category: lipopeptide
• Formula: C51H81ClN14O17
• Monoisotopic mass: 1196.559264946 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2019-04-04 by Maude Pupin [Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 10
• Smiles: CCCCCCC[C@H](CC(=O)N[C@H]1COC(=O)[C@@H](NC(=O)[C@@H](NC(=O)/C(=C/C)/NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC1=O)CO)CCN)CCN)CCCN=C(N)N)CC2=CC=CC=C2)[C@@H](C(=O)O)O)[C@@H](CCl)O)O
  
  
• Graph inference:


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• Monomeric composition :

  1 C10:0-OH(3)

  2 Ser

  3 D-Ser

  4 Dab

  5 D-Dab

  6 Arg

  7 Phe

  8 dhAbu

  9 OH-Asp

  10 4Cl-Thr

• Graph representation: C10:0-OH(3),Ser,D-Ser,Dab,D-Dab,Arg,Phe,dhAbu,OH-Asp,4Cl-Thr @1 @0,2,9 @1,3 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @1,8
  
  
• Atomic structure:

vizualisation:

• Pseudomonas syringae pv. syringae
• gram: negative
• taxid: 321 (view NCBI taxonomy browser)

• Links between organisms producing the syringomycin A1: Pseudomonas syringae pv. syringae

• The structure of syringomycins A1, E and G
  Iacobellis NS, Ballio A, Bossa F, Pucci P, Segre AL, Grgurina I, Bachmann RC, Marino G, Simmaco M, Takemoto JY, FEBS letters , 1989, Sep 11,255(1):27-31.
  DOI: 10.1016/0014-5793(89)81054-3
  pubMed: 2676599

• Characterization of the syringomycin synthetase gene cluster. A link between prokaryotic and eukaryotic peptide synthetases
  Grgurina I, Guenzi E, Galli G, Gross DC, Grandi G, The Journal of biological chemistry , 1998, Dec 4,273(49):32857-63.
  DOI: 10.1074/jbc.273.49.32857
  pubMed: 9830033

  O85168 Q3T5T0 Q52401