didemnin M
- Norine ID: NOR00380
- DOI: 10.26097/nor00380
- Family: didemnin
- Synonym(s): didemnin M;
- Activity: antitumor, immunomodulating
- Category: peptide
- Formula: C67H102N10O19
- Monoisotopic mass: 1350.7322711319998 g/mol
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: partial cyclic
- Number of monomers: 11
- Smiles: CC[C@H](C)[C@@H]1[C@H](CC(=O)O[C@H](C(=O)[C@H](C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N([C@H](C(=O)O[C@@H]([C@@H](C(=O)N1)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H]3CCCN3C(=O)[C@H](C)OC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]4CCC(=O)N4)C)CC5=CC=C(C=C5)OC)C)CC(C)C)C)C(C)C)O
- Graph inference:
- Monomeric composition :
1 Ist 2 Hip 3 Leu 4 Pro 5 NMe-OMe-Tyr 6 Thr 7 D-NMe-Leu 8 Pro 9 Lac 10 Gln 11 pGlu - Graph representation: Ist,Hip,Leu,Pro,NMe-OMe-Tyr,Thr,D-NMe-Leu,Pro,Lac,Gln,pGlu @1,5 @0,2 @1,3 @2,4 @3,5 @0,4,6 @5,7 @6,8 @7,9 @8,10 @9
- Atomic structure:
- Trididemnum solidum
- gram:
- synonyms:
- taxid: 1079459 (view NCBI taxonomy browser)
- Links between organisms producing the didemnin M: Trididemnum solidum
- Seven new didemnins from the marine tunicate Trididemnum solidum
Rinehart KL, Sakai R, Stroh JG, Sullins DW, Journal of the American Chemical Society , 1995, 117 (13), pp. 3734-3748
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