Norine

• Norine ID: NOR00237
• DOI: 10.26097/nor00237
• Family: actinomycin
• Synonym(s): actinomycin Z3;
• Activity: antimicrobial
• Category: chromopeptide
• Formula: C62H83ClN12O18
• Monoisotopic mass: 1318.5636816219999 g/mol
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: double cyclic
• Number of monomers: 11
• Smiles: CC(C)C6NC(=O)C(NC(=O)c3ccc(C)c4OC5=C(C)C(=O)C(N)=C(C(=O)NC1C(=O)NC(C(C)C)C(=O)N2C(C)C(=O)CC2(C(=O)N(C)CC(=O)N(C)C(C)C(=O)OC1(CCl)))C5(=Nc34))C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7C(O)CC(C)N7(C6(=O))
  
  
• Graph inference:


  Run Smiles2Monomers |   Run rBAN



• Monomeric composition and PDB SEQRES:

  1 4Cl-Thr 1 CTH

  2 D-Val 2 DVA

  3 4oxo-5Me-Pro 3 POM

  4 NMe-Gly 4 SAR

  5 NMe-Ala 5 MAA

  6 ChrAct 6 PXZ

  7 Thr 7 THR

  8 D-Val 8 DVA

  9 3OH-5Me-Pro 9 H5M

  10 NMe-Gly 10 SAR

  11 NMe-Val 11 MVA

• Graph representation: 4Cl-Thr,D-Val,4oxo-5Me-Pro,NMe-Gly,NMe-Ala,ChrAct,Thr,D-Val,3OH-5Me-Pro,NMe-Gly,NMe-Val @1,4,5 @0,2 @1,3 @2,4 @3,0 @0,6 @5,7,10 @6,8 @7,9 @8,10 @6,9
  
  
• Atomic structure:

vizualisation:

• Streptomyces sp.
• gram: positive
• synonyms:
• taxid: 1931 (view NCBI taxonomy browser)

• Links between organisms producing the actinomycin Z3: Streptomyces sp.

• Structures of five components of the actinomycin Z complex from Streptomyces fradiae, two of which contain 4-chlorothreonine
  MAUGER AB, Lackner H, Bahner I, Shigematsu N, Pannell LK, Journal of natural products , 2000, Mar,63(3):352-6.
  DOI: 10.1021/np990416u
  pubMed: 10757717

  1a7z

  1a7z

  1a7z