Norine

• Norine ID: NOR00028
• DOI: 10.26097/nor00028
• Family: Calcium dependent antibiotic
• Synonym(s): CDA4a;
• Activity: antimicrobial
• Category: lipopeptide
• Formula: C67H79N14O26
• Monoisotopic mass: 1495.52899377 g/mol
• Comment: CDA shares a similar structure and possibly a related mode of action to other acidic lipopeptide antibiotics, including daptomycin, friulimicins, and amphomycins.
• Source: norine
• Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
• Entry information:
  • status: curated - change status to non-NRP (Norine validators only)
  • last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
  • view all entry history

• Type: partial cyclic
• Number of monomers: 12
• Smiles: CCCC7OC7(C(=O)NC(CO)C(=O)NC5C(C)OC(=O)C(=Cc1c[nH]c2ccccc12)NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(CC(=O)O)NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(Cc3c[nH]c4ccccc34)NC5(=O))c6ccc(O)cc6)C(O)C(N)=O)C(C)CC(=O)O)
  
  
• Graph inference:


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• Monomeric composition :

  1 C6:0-Ep(2)	2 Ser	3 Thr	4 D-Trp	5 Asp	6 Asp	7 D-Hpg	8 Asp	9 Gly	10 D-OH-Asn	11 3Me-Glu	12 dh-Trp

• Graph representation: C6:0-Ep(2),Ser,Thr,D-Trp,Asp,Asp,D-Hpg,Asp,Gly,D-OH-Asn,3Me-Glu,dh-Trp @1 @0,2 @1,3,11 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @2,10
  
  
• Atomic structure:

vizualisation:

• Streptomyces roseosporus
• gram: positive
• synonyms: Streptomyces filamentosus,Streptomyces venezuelae subsp. roseospori,Streptomyces roseisporus
• taxid: 67294 (view NCBI taxonomy browser)

• Streptomyces coelicolor
• gram: positive
• synonyms: Actinomyces coelicolor,Nocardia coelicolor,Cladothrix coelicolor,Streptothrix coelicolor
• taxid: 1902 (view NCBI taxonomy browser)

• OS-F68576
• gram:
• synonyms:
• taxid: (view NCBI taxonomy browser)

• Links between organisms producing the CDA4a: Streptomyces roseosporus, Streptomyces coelicolor, OS-F68576

• Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor
  Hojati Z, Milne C, Harvey B, Gordon L, Borg M, Flett F, Wilkinson B, Sidebottom PJ, Rudd BA, Hayes MA, Smith CP, Micklefield J, Chemistry and biology , 2002, Nov,9(11):1175-87.
  pubMed: 12445768

  Q9Z4X6 Q9Z4X5 Q8CJX2

  BGC0000315