apicidin D3
- Norine ID: NOR01111
- DOI: 10.26097/nor01111
- Family: apicidin
- Synonym(s): apicidin D3;
- Activity: antitumor, toxin
- Category: peptide
- Formula: C34H51N5O6
- Monoisotopic mass: 625.3839343889999 g/mol
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: putative - change status to non-NRP (Norine validators only)
- last modification date: 2018-12-01 by Emma Ricart Altimiras [Swiss Institute of Bioinformatics, SIB]
- view all entry history
- Type: cyclic
- Number of monomers: 4
- Smiles: CC[C@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCCC(C)O
- Graph inference:
- Monomeric composition :
1 C10:0-OH(9)-NH2(2) 2 D-Hpr 3 Ile 4 OMe-Trp - Graph representation: C10:0-OH(9)-NH2(2),D-Hpr,Ile,OMe-Trp @1,3 @0,2 @1,3 @0,2
- Atomic structure:
- Fusarium
- gram:
- synonyms:
- taxid: 5506 (view NCBI taxonomy browser)
- Links between organisms producing the apicidin D3: Fusarium
- Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal alpha-keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities
Singh SB, Zink DL, Liesch JM, Mosley RT, Dombrowski AW, Bills GF, Darkin-Rattray SJ, Schmatz DM, Goetz MA, The Journal of organic chemistry , 2002, Feb 8,67(3):815-25.
DOI: 10.1021/jo016088w
pubMed: 11856024
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