amphomycin A1437 B
- Norine ID: NOR00763
- DOI: 10.26097/nor00763
- Family: friulimicin
- Synonym(s): amphomycin A1437 B;
- Activity: antimicrobial
- Category: lipopeptide
- Formula: C59H93N13O20
- Monoisotopic mass: 1303.665982481 g/mol
- Comment: The acyl residue is essential for antibiotic activity.
- Source: norine
- Contributor (creation): Norine Team [CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- Entry information:
- status: curated - change status to non-NRP (Norine validators only)
- last modification date: 2018-09-12 by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
- view all entry history
- Type: partial cyclic
- Number of monomers: 12
- Monomeric composition and PDB SEQRES:
1 iC14:1(3) 1 LNG 2 Asp 2 ASP 3 Dbu 3 VLL 4 Hpr 4 CPI 5 bMe-Asp 5 2AS 6 Asp 6 ASP 7 Gly 7 GLY 8 Asp 8 ASP 9 Gly 9 GLY 10 D-Dbu 10 VDL 11 Val 11 VAL 12 Pro 12 PRO - Graph representation: iC14:1(3),Asp,Dbu,Hpr,bMe-Asp,Asp,Gly,Asp,Gly,D-Dbu,Val,Pro @1 @0,2 @1,3,11 @2,4 @3,5 @4,6 @5,7 @6,8 @7,9 @8,10 @9,11 @2,10
- Atomic structure:
Peptide's atomic structure image is not available because smiles is not present.
- Actinoplanes friuliensis
- gram: positive
- taxid: 196914 (view NCBI taxonomy browser)
- Streptomyces canus
- gram: positive
- taxid: 58343 (view NCBI taxonomy browser)
- Links between organisms producing the amphomycin A1437 B: Actinoplanes friuliensis, Streptomyces canus
- An acyl-CoA dehydrogenase is involved in the formation of the Delta cis3 double bond in the acyl residue of the lipopeptide antibiotic friulimicin in Actinoplanes friuliensis
Heinzelmann E, Berger S, Muller C, Hartner T, Poralla K, Wohlleben W, Schwartz D, Microbiology , 2005, Jun,151(Pt 6):1963-74.
DOI: 10.1099/mic.0.27844-0
pubMed: 15942003
- Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides
Grunewald J, Marahiel MA, Microbiology and molecular biology reviews : MMBR , 2006, Mar,70(1):121-46.
DOI: 10.1128/MMBR.70.1.121-146.2006
pubMed: 16524919
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