NORINE is a platform that includes a database of nonribosomal peptides together
with tools for their analysis. Norine currently contains 1744 peptides.
The name Norine stands for Nonribosomal peptides, with ine as a typical ending of
peptide names.
For each peptide, the database stores its structure as well as various annotations such as the biological
activity, producing organisms, bibliographical references among others. The database can be queried in order to search
for peptides through their annotations as well as through their monomeric structures. In the latter case, the user can
specify either the composition, the whole structure or a structural pattern (possibly including "undefined monomers")
of the searched peptide.
To cite Norine
Norine is freely available to everybody, under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
(CC BY-NC-SA 4.0)
See terms of use for more details. If you use the database, please cite:
Norine: update of the nonribosomal peptide resource. Areski Flissi, Emma Ricart, Clémentine Campart, Mickaël Chevalier, Yoann Dufresne, Juraj Michalik, Philippe Jacques, Christophe Flahaut, Frédéric Lisacek, Valérie Leclčre and Maude Pupin
Nucleic Acids Research, Nov. 2019, gkz1000, https://doi.org/10.1093/nar/gkz1000
News
May 2023: Chapter in Methods in Molecular Biology 
- Norine: Bioinformatics Methods and Tools for the Characterization of Newly Discovered Nonribosomal Peptides, Flissi, A., Duban, M., Jacques, P., Leclère, V., Pupin, M., https://dx.doi.org/10.1007/978-1-0716-3214-7_16
July 2022: Award for Norine!
Norine received the Open Science Research Data Award 2022.
More info
January 2022: New release for Norine
- Norine webapp and database migration to new server. It is now hosted on the cloud of ULille University.
Norine is now accessible with the new URL
https://norine.univ-lille.fr
(The previous URL is automatically redirected to the new one). - New activity prediction REST service: https://norine.univ-lille.fr/service.jsp
- Activity Prediction interface can now be requested by either monomeric graph or SMILES: https://norine.univ-lille.fr/norine/activityform.jsp
- Bugs fix
April 2021: New release for Norine!
New tool developed by Ammar Abdo for activity prediction of NRPs from their graph
(Activity Prediction)
Monomer structure fingerprints: an extension of the monomer composition version for peptide databases. Ammar Abdo, Eissa Ghaleb, Naser K. A. Alajmi, Maude Pupin
The web interface has been developped by Clementine Campart
Journal of Computer-Aided Molecular Design volume 34, pages 1147-1156 (2020)
https://link.springer.com/article/10.1007/s10822-020-00336-8- It is now possible to remove NRPs or set NRPs status as non-NRP (Norine validators only) and to see list of deprecated NRPs. Deprecated NRPs don't appear in structure or annotations search results.
- Bugs fix
Jul. 2020: New release
New tool developed by Emma Ricart from the SIB (Swiss Institute of Bioinformatics):
a tool for the analysis of MS/MS from peptidic natural products
(NRPro)
- Update of the pipeline that extract and filter NRPs from external resources
- Adding of missing StreptomeDB links
- Bugs fix
Dec. 2019: Norine release
- Each Norine NRP has been attributed a DOI (Digital Object Identifier):
To cite a specific peptide, you can now also use its DOI, composed of the 10.26097 prefix and the Norine ID, e.g. https://doi.org/10.26097/nor00342 for the peptide #NOR00342 - Using the rBAN tool to display image of the atomic structure with monomers annotations by infering SMILES, on result page (example)
- Updating Norine licensing and terms of use, see here for more information
Sept. 2019: Major update of the Norine database!
- About 540 new NRPs have been added to the database, automatically extracted and filtered from external resources (MIBiG, BIRD and StreptomeDB)
- These new NRPs are tagged with the 'unreviewed' status
- It is now possible to search peptides according to their origin, i.e. the resource from which it comes from
April 2019: New release for Norine
software integration:
Run rBAN directly from peptide result page to infer monomeric structure from SMILES- Database refactoring to improve the handling of peptides' references and journals
- Search for peptides containing some links to external databases (PubChem, PDB...)
- Minor bugs fix
Dec. 2018: Norine database updated!
- About 500 peptides SMILES added or updated after curation process. Thanks to Emma Ricart from SIB, Swiss Institute of Bioinformatics, for her contribution!
- Displaying contributors (creation or modification), on both peptides and monomers page, and all entry history
11/2018: New features for Norine
- Norine contributors are now visible in Contributors tab!
Access contributions (submitted peptides and modification proposals) for each contributor. - Displaying more information on recently added or modified peptides (submission date, validator, peptide comment, modifications...)
09/2018: Norine database updated: new SMILES.
- Adding new SMILES to peptides: SMILES is now specified for more than 500 peptides (Thanks to Emma Ricart from SIB, Swiss Institute of Bioinformatics, for her contribution).
07/2018: Norine released!
- Adding missing molecular formulas: now formula is specified for more than 95% of Norine peptides (thanks to Mickael Chevalier from ICV, Institut Charles Viollette for his contribution)
- Run Smiles2Monomers directly from peptide result page to infer monomeric structure from SMILES
- Updating Smiles2Monomers lib. to handle wrong SMILES
- Bug corrections
03/2018: Norine released!
- Monoisotopic mass is now automatically calculated from molecular formula for both monomers and peptides (Thanks to Emma Ricart from SIB, Swiss Institute of Bioinformatics, for her help)
- Upgrading Smiles2Monomers lib.
- Bug corrections
10/2017: Norine released!
- New features in annotations search: filter peptides that have a smiles defined
- Taxonomy tree have been updated for producing organisms
- New REST service: get peptides with smiles (see documentation)
- Bug corrections
12/2016: New release of Norine
- New annotations search interface: create dynamic and advanced requests
- Refactoring of norine database structure
- Use now the Smiles2Monomers tool as a web service : see here
- New peptide result page
- MyNorine: enhanced interfaces for defining organisms' taxonomy and monomers' clustering
06/2016: Norine is now referenced on OMICStool
- OMICtools is a workflow for multi-omics data analysis. Norine is referenced in the category :
Dataset > Drug discovery > Peptide prediction
01/2016: New release of MyNorine
- MyNorine now automatically compares the monomeric composition of a new peptide submission, with the composition inferred by Smiles2Monomers, if the SMILES is given.
- Updating the S2M wrapper.
- New publication available
- Norine, the knowledgebase dedicated to non-ribosomal peptides, is now open to crowdsourcing.
Areski Flissi, Yoann Dufresne, Juraj Michalik, Laurie Tonon, Stéphane Janot, Laurent Noé, Philippe Jacques, Valérie Leclčre and Maude Pupin
Nucl Acids Res 2016, Nov. 2015, doi: 10.1093/nar/gkv1143
- Norine, the knowledgebase dedicated to non-ribosomal peptides, is now open to crowdsourcing.
Areski Flissi, Yoann Dufresne, Juraj Michalik, Laurie Tonon, Stéphane Janot, Laurent Noé, Philippe Jacques, Valérie Leclčre and Maude Pupin
- Minor bugs fixed
09/2015: New graphical editor for peptides
- New editor for Norine: the editor allowing to draw monomeric structure/composition of NRPs is now coded in JavaScript.
- New visualisator for peptides in result pages.
08/2015: New features for Norine!
- New features for Norine: additional smiles information for some peptide, and atomic structure image (automatically generated using the Smiles2Monomers tool from smiles) for monomers and peptides
- MyNorine: the tool allows now to also submit proposal of modifications for NRPs entries; theses proposals will be manually checked and validated by the Norine team
- New peptides added to the database, and some entries have been corrected.
01/2015: New release of Norine!
- Refactoring of Norine code for optimization purpose
- New features: save XML/Json data for each peptide, import peptide template to MyNorine
- MyNorine : a new interface dedicated to the submission of new non-ribosomal petides to Norine database:
- Norine REST Services: useful REST services to access the Norine database:
- Bugs fixed
07/2013: Norine is still alive
- Norine contains now 1164 peptides and others will come this automn
- Some entries have been corrected
- Norine code has moved under Model-view-controller architecture, but the functionalities are still effective
- A new structure search form is available with improved features (see help for more details)
- Structure search can be done by monomer fingerprint, as presented in our article :
- A new fingerprint to predict nonribosomal peptides activity.
Abdo A, Caboche S, Leclere V, Jacques P, Pupin M.
J Comput Aided Mol Des. 2012 Oct;26(10):1187-94, doi: 10.1007/s10822-012-9608-4
- A new fingerprint to predict nonribosomal peptides activity.
- Minor bugs fixed
04/2010: Norine features are upgraded:
- Norine contains now 1122 peptides
- A new version of the structure editor is available
- Monomers and peptides are presented grouped to help their search
- You can now have the list of peptides produced by an organism
- Minor bugs were corrected
06/22/2009: Norine gets enriched by new features:
- You can download Norine data as XML or text files
- Similarity search is now available here
03/10/2009: New release of Norine:
- The new release of Norine contains 1071 peptides
- Fatty acids are encoded and all fatty acid variants of a peptide are available
- Structural pattern matching allows a search for peptides containing the
pattern substructure with a given minimal number of monomers. for more information see:
- Structural pattern matching of nonribosomal peptides,
Segolene Caboche, Maude Pupin, Valerie Leclere, Philippe Jacques and Gregory Kucherov,
BMC Structural Biology 2009, 9:15, doi: 10.1186/1472-6807-9-15
- Structural pattern matching of nonribosomal peptides,
- A more detailled description of each monomer is available (e.g. molecular weight, SMILES, molecular formula)
08/08/2008: Norine gets enriched by new features:
- You can submit a new peptide or modifications
- For each peptide, you can add comments
- Changes in search forms
Norine has been presented for the first time to the JOBIM 06 conference (poster and flash presentation).
In June 2007, a Norine poster has been presented to the 7th congress of the French Society for Microbiology in Nantes, where it has been awarded best poster over than more 300 posters presented.
Last entries (63)
-
Keanumycin A,
added by Norine Team
[CRIStAL (UMR CNRS 9189), ex-LIFL, France, Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
on 2023-02-01
(modification)
,
Add taxId for organism
-
Anikasin,
added by Matthieu Duban
[UMR BioEcoAgro 1158 ICV]
on 2023-01-27
(modification)
,
Change for monomers isomery L->D
- Keanumycin B, added by Sebastian Götze [Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute Jena e.V.] on 2023-01-24 (creation) ,
- Keanumycin A, added by Sebastian Götze [Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute Jena e.V.] on 2023-01-24 (creation) ,
-
Orfamide C,
added by Matthieu Duban
[UMR BioEcoAgro 1158 ICV]
on 2022-09-07
(modification)
,
taxonomy error
-
Orfamide A,
added by Matthieu Duban
[UMR BioEcoAgro 1158 ICV]
on 2022-09-07
(modification)
,
taxonomy error
-
Orfamide B,
added by Matthieu Duban
[UMR BioEcoAgro 1158 ICV]
on 2022-09-07
(modification)
,
taxonomy error
- heptarhizin, added by Maria Dell [ETH Zuerich Institut für Mikrobiologie HCI G 433 Vladimir-?Prelog-Weg 1-5/10 8093 Zürich Switzerland] on 2022-06-02 (creation) ,
- Jagaricin, added by Matthieu Duban [UMR BioEcoAgro 1158 ICV] on 2020-09-29 (creation) ,
- Pseudodesmin B, added by Alexandre Bricout [Institut Charles Viollette] on 2020-09-24 (creation) ,
-
Bananamide G,
added by Alexandre Bricout
[Institut Charles Viollette]
on 2020-09-14
(creation)
,
D- and L-isomeries of monomers are predictive according to synthetase sequences. Bananamides D to G, produced by Pseudomonas sp. COW3, have shown antimicrobial activities against Pythium myriotylum and Pyricularia oryzae
-
Bananamide E,
added by Alexandre Bricout
[Institut Charles Viollette]
on 2020-09-14
(creation)
,
D- and L-isomeries of monomers are predictive according to synthetase sequences. Bananamides D to G, produced by Pseudomonas sp. COW3 have shown antimicrobial activities against Pythium myriotylum and Pyricularia oryzae.
-
Bananamide F,
added by Alexandre Bricout
[Institut Charles Viollette]
on 2020-09-14
(creation)
,
D- and L-isomeries of monomers are predictive according to synthetase sequences. Bananamides D to G, produced by Pseudomonas sp. COW3, have shown antimicrobial activities against Pythium myriotylum and Pyricularia oryzae
-
Bananamide D,
added by Alexandre Bricout
[Institut Charles Viollette]
on 2020-09-14
(creation)
,
D- and L- isomeries of monomers are predictive according to synthetase sequences. Antifungal activity described.
- Virginiafactin A, added by Sebastian Götze [University Koblenz-Landau Faculty 7: Natural and Environmental Sciences] on 2020-05-02 (creation) ,
-
quinomycin B,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2020-04-29
(modification)
,
Change the link to the right PubChem entry and addition of a reference that describes the presence of NMe-aIle
-
koshikamide A1,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2020-04-28
(modification)
,
I build the SMILES from the one of koshikamide A2
- Virginiafactin C, added by Sebastian Götze [University Koblenz-Landau Faculty 7: Natural and Environmental Sciences] on 2019-12-18 (creation) ,
- Virginiafactin B, added by Sebastian Götze [University Koblenz-Landau Faculty 7: Natural and Environmental Sciences] on 2019-12-18 (creation) ,
- Virginiafactin D, added by Sebastian Götze [University Koblenz-Landau Faculty 7: Natural and Environmental Sciences] on 2019-12-18 (creation) ,
-
lokisin,
added by Sebastian Götze
[University Koblenz-Landau
Faculty 7: Natural and Environmental Sciences]
on 2019-02-20
(modification)
,
Anikasins structure was fully elucidated. It seems likely that anikasin and lokisin are the same compound. Unfortunately a direct comparison was not possible.
-
Jessenipeptin,
added by Sebastian Götze
[University Koblenz-Landau
Faculty 7: Natural and Environmental Sciences]
on 2019-01-28
(modification)
,
Few structural modifications
-
enniatin F,
added by Emma Ricart Altimiras
[Swiss Institute of Bioinformatics, SIB]
on 2018-12-14
(modification)
,
SMILES removed (see rBAN article)
-
vibriobactin,
added by Emma Ricart Altimiras
[Swiss Institute of Bioinformatics, SIB]
on 2018-12-14
(modification)
,
SMILES changed.
-
keramamide L,
added by Emma Ricart Altimiras
[Swiss Institute of Bioinformatics, SIB]
on 2018-12-14
(modification)
,
SMILES added
-
anguibactin,
added by Emma Ricart Altimiras
[Swiss Institute of Bioinformatics, SIB]
on 2018-12-14
(modification)
,
SMILES corrected.
-
oriamide,
added by Emma Ricart Altimiras
[Swiss Institute of Bioinformatics, SIB]
on 2018-12-14
(modification)
,
SMILES added
- Entolysin A, added by Mickael Chevalier [Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France] on 2018-12-02 (creation) ,
-
Jessenipeptin,
added by Sebastian Götze
[University Koblenz-Landau
Faculty 7: Natural and Environmental Sciences]
on 2018-10-17
(creation)
,
GENBANK access code for the genome of the producer organism: PHSU01000000
-
Anikasin,
added by Sebastian Götze
[University Koblenz-Landau
Faculty 7: Natural and Environmental Sciences]
on 2018-10-17
(creation)
,
x-ray structure: CCDC 1566928 - Cambridge Crystallographic Data Centre Genome: LVEJ01000000 - DDBJ/ENA/GenBank
-
empedopeptin,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2018-07-24
(modification)
,
Deletion of a part of the comments that were concerning another peptide.
-
A51568,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2018-07-18
(modification)
,
Change of the SMILES to have the correct one. Deletion of the wrong PubChem link. Addition of a synonym.
-
cyclosporin F,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2018-07-17
(modification)
,
Change of the molecular formula by using the SMILES
-
iturin C-1,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2018-07-17
(modification)
,
Addition of the aromaticity in the SMILES and addition of a link to a pubchem entry
-
milkisin C,
added by Schlusselhuber Margot
[Université de Caen Normandie
EA4651 ABTE, Equipe MALIM]
on 2018-06-11
(modification)
,
reference added following article acceptation
-
milkisin B,
added by Schlusselhuber Margot
[Université de Caen Normandie
EA4651 ABTE, Equipe MALIM]
on 2018-06-11
(creation)
,
Isomery of each monomer is only predictive, not experimentally verified. It has been assigned by comparison with other members of the amphisin family.
-
milkisin D,
added by Schlusselhuber Margot
[Université de Caen Normandie
EA4651 ABTE, Equipe MALIM]
on 2018-06-11
(creation)
,
Isomery of each monomer is only predictive, not experimentally verified. It has been assigned by comparison with other members of the amphisin family.
-
milkisin A,
added by Schlusselhuber Margot
[Université de Caen Normandie
EA4651 ABTE, Equipe MALIM]
on 2018-06-11
(creation)
,
Isomery of each monomer is only predictive, not experimentally verified. It has been assigned by comparison with other members of the amphisin family.
-
cyclosporin F,
added by Manon Haudrechy
[Université Lille 1, France]
on 2018-06-05
(modification)
,
Wrong peptide SMILES because of a wrong PubChem entry (6450481) Abu (wrong) instead of Nva (verified by the article)
-
destruxin B,
added by Manon Haudrechy
[Université Lille 1, France]
on 2018-06-05
(modification)
,
Wrong peptide SMILES because of a wrong PubChem entry ( 5458450) Wrong monomer : Hiv is replaced by 4-Me-Hva PubChem entry modified (23306078)
-
discodermin A,
added by Manon Haudrechy
[Université Lille 1, France]
on 2018-06-04
(modification)
,
Wrong SMILES and molecular formula because of a wrong PubChem entry (16132162)
-
massetolide A,
added by Manon Haudrechy
[Université Lille 1, France]
on 2018-06-04
(modification)
,
Wrong peptide SMILES (missing a CH3 in the fatty acid) because of wrong PubChem entry.
-
enniatin H,
added by Manon Haudrechy
[Université Lille 1, France]
on 2018-06-01
(modification)
,
Hmp instead of 4-NMe-Hva (wrong peptide SMILES). Detected by s2m and confirmed in the article.
-
didemnin C,
added by Manon Haudrechy
[Université Lille 1, France]
on 2018-06-01
(modification)
,
Wrong SMILES and PubChem entry
-
aureobasidin B,
added by Manon Haudrechy
[Université Lille 1, France]
on 2018-06-01
(modification)
,
Wrong peptide SMILES (Leu instead of Ile) because of a wrong SMILES in the PubChem entry 3080364
-
beauvericin A,
added by Manon Haudrechy
[Université Lille 1, France]
on 2018-05-31
(modification)
,
Phe was wrong and replaced by NMe-Phe (link to a wrong PubChem entry)
-
enniatin I,
added by Manon Haudrechy
[Université Lille 1, France]
on 2018-05-31
(modification)
,
Hmp instead of 4-Me-Hva (wrong peptide SMILES). Detected with s2m and confirmed in the article.
-
iturin C-1,
added by Manon Haudrechy
[Université Lille 1, France]
on 2018-05-31
(modification)
,
Wrong Fatty acid (peptide SMILES and FA name)
-
isariin B,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2018-03-08
(modification)
,
Addition of the SMILES and of a link to PubChem entry and of the molecular formula
-
isariin C,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2018-03-08
(modification)
,
Addition of the SMILES and of a link to PubChem entry
-
pseudofactin I,
added by Piotr Biniarz
[University of Wroclaw, PL]
on 2018-02-20
(creation)
,
Pseudofactin I is one of four currently known cyclic lipopeptides of a new family (pseudofactins).
-
milkisin C,
added by Schlusselhuber Margot
[Université de Caen Normandie
EA4651 ABTE, Equipe MALIM]
on 2017-10-23
(creation)
,
Isomery of each monomer is only predictive, not experimentally verified. It has been assigned by comparison with other members of the amphisin family.
-
bergofungin D,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2017-07-31
(modification)
,
Change of the monomeric structure (verified from the SMILES and the article) ; addition of links to PubChem ; the SMILES ; formula and molecular weight from PubChem
-
bergofungin B,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2017-07-31
(modification)
,
Change of the monomeric structure (verified from the SMILES and the article) ; addition of links to PubChem ; the SMILES ; formula and molecular weight from PubChem
-
bergofungin C,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2017-07-31
(modification)
,
Addition of links to PubChem ; the SMILES ; formula and molecular weight from PubChem
-
bergofungin A,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2017-06-29
(modification)
,
Addition of links to PDB and PubChem ; the SMILES ; a reference ; formula and molecular weight from PubChem
-
CDA4b,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2017-03-29
(modification)
,
Addition of a link to PubChem
-
Val-gramicidin C,
added by Maude Pupin
[Université Lille 1, France, CRIStAL (UMR CNRS 9189), ex-LIFL, France]
on 2017-02-02
(modification)
,
add of formula, molecular weight, SMILES and synonyms
-
Orfamide C,
added by Mickael Chevalier
[Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
on 2017-01-02
(modification)
,
Add smiles and formula
-
Orfamide A,
added by Mickael Chevalier
[Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
on 2017-01-02
(modification)
,
Add smiles and formula
-
Orfamide B,
added by Mickael Chevalier
[Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
on 2017-01-02
(modification)
,
Add smiles and formula
-
putisolvin II,
added by Mickael Chevalier
[Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
on 2017-01-02
(modification)
,
Add smiles and formula
-
putisolvin I,
added by Mickael Chevalier
[Charles Viollette Institute, ProBioGEM team, Lille, France, University of Lille, France]
on 2017-01-02
(modification)
,
Add smiles and formula
What are nonribosomal peptides
Bacteria or fungi feature peptides that are synthesized through a ribosome independent pathway rather than through the
classical pathway from the DNA transcription to the translation of mRNA into peptides on the ribosome. This
alternative pathway is called NonRibosomal Peptide Synthesis. It is performed by a huge protein complex called
a NonRibosomal Peptide Synthetase (NRPS). This is a modularly organized multi-enzyme complex that bears
template and biosynthetic machinery at the same time. The molecules synthesized by NRPS are short (two to about fifty
monomers), include a high proportion of nonproteogenic amino acids and often contain amino acids connected by bonds
other than peptide or disulfide bonds. The diversity of amino acids incorporated in NRPS peptides is large and it is
why we prefer to speak of monomers rather than amino acids. Therefore the primary structure of nonribosomal
peptides is not always linear. They can form cycles (partial or not) and branchings.
Nonribosomal peptides have a broad range of biological activities and pharmacological properties, for example
immunomodulating, iron chelating or antimicrobial activities. The latter is illustrated by the famous penicillin which is
synthesized from ACV-tripeptide precursor produced by NRPS pathway.
For more details about the monomers stored in Norine, you can read our paper :
Diversity of monomers in nonribosomal peptides: towards the prediction of origin and biological activity.
Caboche S, Leclere V, Pupin M, Kucherov G, Jacques P.
J Bacteriol. 2010 Oct;192(19):5143-50, doi: 10.1128/JB.00315-10
Latest news:
May 2023: Chapter in Methods in Molecular Biology
- Norine: Bioinformatics Methods and Tools for the Characterization of Newly Discovered Nonribosomal Peptides, Flissi, A., Duban, M., Jacques, P., Leclère, V., Pupin, M., https://dx.doi.org/10.1007/978-1-0716-3214-7_16
July 2022: Award for Norine!
- Norine received the Open Science Research Data Award 2022.
More info
January 2022: New release for Norine
- Norine webapp and database migration to new server. It is now hosted on the cloud of ULille University.
Norine is now accessible with the new URL
https://norine.univ-lille.fr
(The previous URL is automatically redirected to the new one). - New activity prediction REST service: https://norine.univ-lille.fr/service.jsp
- Activity Prediction interface can now be requested by either monomeric graph or SMILES: https://norine.univ-lille.fr/norine/activityform.jsp
- Bugs fix
April 2021: New release for Norine!
-
New tool developed by Ammar Abdo for activity prediction of NRPs from their graph
(Activity Prediction)
Monomer structure fingerprints: an extension of the monomer composition version for peptide databases. Ammar Abdo, Eissa Ghaleb, Naser K. A. Alajmi, Maude Pupin
The web interface has been developped by Clementine Campart
Journal of Computer-Aided Molecular Design volume 34, pages 1147-1156 (2020)
https://link.springer.com/article/10.1007/s10822-020-00336-8 - It is now possible to remove NRPs or set NRPs status as non-NRP (Norine validators only) and to see list of deprecated NRPs. Deprecated NRPs don't appear in structure or annotations search results.
- Bugs fix
Jul. 2020: New release
-
New tool developed by Emma Ricart from the SIB (Swiss Institute of Bioinformatics):
a tool for the analysis of MS/MS from peptidic natural products
(NRPro)
- Update of the pipeline that extract and filter NRPs from external resources
- Adding of missing StreptomeDB links
- Bugs fix
Dec. 2019: Norine release
- Each Norine NRP has been attributed a DOI (Digital Object Identifier):
To cite a specific peptide, you can now also use its DOI, composed of the 10.26097 prefix and the Norine ID, e.g. https://doi.org/10.26097/nor00342 for the peptide #NOR00342 - Using the rBAN tool to display image of the atomic structure with monomers annotations by infering SMILES, on result page (example)
- Updating Norine licensing and terms of use, see here for more information
SiteMap
 Peptides
|
 Monomers
|
 MyNorine
|
 Smiles2Monomer
|
 Kendrick Formula Predictor
|
 rBAN
|
 NRPro
|
 API
|
Contact informations
This project results from a tight collaboration between the Bonsai
bioinformatics research group of CRIStAL
(Centre de Recherche en Informatique, Signal et Automatique de Lille, ex-LIFL (Laboratoire d'Informatique
Fondamentale de Lille) and Inria (Institut National de Recherche en
Informatique et en Automatique) and the NRPS team from the ProBioGem laboratory (Laboratoire des
Procédés Biologiques Génie Enzymatique et Microbien).
The Norine Team is composed of contributors of these two labs.
All inquiries should be sent to Norine (norine_at_univ-lille.fr).
This project is supported by bilille and the French Institute of Bioinformatics (IFB).
Norine database contributors
Norine is mainly maintained by the Norine team composed of members of the CRIStAL lab. (CNRS, the French National Scientific Research Center, and University of Lille, France)
and the ProbioGem team of the Charles Viollette Institute (ICV), France.
People who also contributed to the Norine database by submitting new NRPs or modification proposals: